{"id":"W4403960916","doi":"10.1016/j.gendis.2024.101444","title":"CRISPR/Cas9 screening reveals Zfp607b as a novel transcription factor regulating myogenesis","year":2024,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Agricultural Science and Technology Innovation Program; National Key Scientific Instrument and Equipment Development Projects of China; Chinese Academy of Agricultural Sciences; National Natural Science Foundation of China; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"CRISPR; Myogenesis; Transcription factor; Biology; Genetics; Computational biology; CRISPR interference; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005515141,0.0002172645,0.0001630119,0.00006237297,0.0001604594,0.00005665993,0.0001522467,0.0001423402,0.0001466571],"category_scores_gemma":[0.00006396282,0.0002081529,0.0002413686,0.000124323,0.00007662421,0.00001298918,0.00005666302,0.00005695337,0.0000291167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000826471,"about_ca_system_score_gemma":0.00007856401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003994231,"about_ca_topic_score_gemma":0.00001436521,"domain_scores_codex":[0.99877,0.00005598137,0.0002107924,0.0005288011,0.0001300915,0.0003043366],"domain_scores_gemma":[0.999451,0.00002449204,0.00004110256,0.0002982667,0.00004802018,0.0001371232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802693,0.0000636515,0.002748522,0.0001080605,0.0001266985,0.000004429427,0.0000559752,0.0002170175,0.9542373,0.0001787153,0.001028572,0.04105081],"study_design_scores_gemma":[0.002606748,0.001146384,0.239023,0.0005321965,0.000898996,0.00007426062,0.001379064,0.002160686,0.6065143,0.00333568,0.1398269,0.002501777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628634,0.0272747,0.008529401,0.000222887,0.0002839991,0.0001927042,0.0001903222,0.00009382452,0.0003487103],"genre_scores_gemma":[0.9971151,0.0004590709,0.000487362,0.0004533753,0.0004478782,0.00005653771,0.000384664,0.00004073135,0.0005552481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.347723,"threshold_uncertainty_score":0.8488228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848372111309138,"score_gpt":0.2804333889483885,"score_spread":0.2619496678352972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}