{"id":"W4403960916","doi":"10.1016/j.gendis.2024.101444","title":"CRISPR/Cas9 screening reveals Zfp607b as a novel transcription factor regulating myogenesis","year":2024,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Agricultural Science and Technology Innovation Program; National Key Scientific Instrument and Equipment Development Projects of China; Chinese Academy of Agricultural Sciences; National Natural Science Foundation of China; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"CRISPR; Myogenesis; Transcription factor; Biology; Genetics; Computational biology; CRISPR interference; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002453412,0.0005484542,0.0006422309,0.0006137707,0.0003777248,0.0004667455,0.0005580899,0.000586428,0.002429944],"category_scores_gemma":[0.0001994857,0.0002198582,0.0004657795,0.0003838587,0.0003297567,0.0001732261,0.00034127,0.0007578333,0.001791512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005637272,"about_ca_system_score_gemma":0.0004116707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002165984,"about_ca_topic_score_gemma":0.002559637,"domain_scores_codex":[0.9996393,0.00001703609,0.00003899746,0.00009808056,0.0001534571,0.00005313359],"domain_scores_gemma":[0.9998498,0.00002227416,0.00003704428,0.00001368429,0.00001813641,0.00005899377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003913825,0.00001335775,0.0002219349,0.00002827739,0.000004486314,0.000103029,0.000006989858,0.00008060979,0.9980332,0.00008613837,0.0001313583,0.001251407],"study_design_scores_gemma":[0.00002309572,0.00006536786,0.003949994,0.00001202399,0.00002365592,0.0004238511,0.00001687836,0.00442938,0.9851804,0.00007885899,0.005782618,0.0000138616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9210192,0.002768436,0.05993974,0.0005662171,0.0001890922,0.0002339571,0.007099513,0.002283864,0.005899974],"genre_scores_gemma":[0.9387814,0.001127253,0.04298772,0.0003939039,0.00001873702,0.0001297998,0.007927894,0.0003083457,0.008324965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429944,"threshold_uncertainty_score":0.008128941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848372111309138,"score_gpt":0.2804333889483885,"score_spread":0.2619496678352972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}