{"id":"W4403966956","doi":"10.1084/jem.20240942","title":"Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Hospital Foundation; Hospital for Sick Children","funders":"Stavros Niarchos Foundation; Hospital for Sick Children; Ministero della Salute; Fondation Bettencourt Schueller; CHIST-ERA; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; National Health and Medical Research Council; SCOR Corporate Foundation for Science; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Meyer Foundation; Rockefeller University; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Fondation pour la Recherche Médicale; JPB Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut des maladies génétiques Imagine; National Center for Advancing Translational Sciences; Medical Research Council; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute; Fondazione IRCCS Policlinico San Matteo; St. Giles Foundation","keywords":"Virology; Encephalitis; Biology; Virus; Flaviviridae; Japanese encephalitis; Flavivirus; Togaviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002953871,0.0006183358,0.0004169291,0.0009009058,0.001058433,0.0005440714,0.0002390866,0.0005730155,0.002220198],"category_scores_gemma":[0.001746384,0.0002646322,0.0002263185,0.0007369294,0.0006096329,0.0006278005,0.0004461522,0.0005915536,0.0002147487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003095888,"about_ca_system_score_gemma":0.0003583941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002276885,"about_ca_topic_score_gemma":0.002289589,"domain_scores_codex":[0.9997026,0.00005621165,0.00005385722,0.00006900766,0.00005140686,0.00006691909],"domain_scores_gemma":[0.9994135,0.0001488578,0.0001811985,0.00004354254,0.00005782726,0.0001551147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003480466,0.00005809318,0.973381,0.00003982806,0.00003355699,0.01836755,0.0006007057,0.00004871317,0.001922136,0.00006232441,0.0002208004,0.004917221],"study_design_scores_gemma":[0.00003818551,0.00053574,0.9121176,0.00004873653,0.00006484544,0.08337487,0.001339148,0.0002709242,0.0007442296,0.0001874155,0.001261818,0.00001642968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976725,0.0005118261,0.00005808625,0.0001002471,0.00001511313,0.0000137461,0.00005597326,0.000006363167,0.001566102],"genre_scores_gemma":[0.9995783,0.0001579395,0.00004181603,0.00004606739,0.00002134341,0.000004460755,0.0000454084,9.549408e-7,0.0001036309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002276885,"threshold_uncertainty_score":0.007427275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635564993410748,"score_gpt":0.3259671236904907,"score_spread":0.2996114737563832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}