{"id":"W4403966956","doi":"10.1084/jem.20240942","title":"Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Hospital Foundation; Hospital for Sick Children","funders":"Stavros Niarchos Foundation; Hospital for Sick Children; Ministero della Salute; Fondation Bettencourt Schueller; CHIST-ERA; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; National Health and Medical Research Council; SCOR Corporate Foundation for Science; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Meyer Foundation; Rockefeller University; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Fondation pour la Recherche Médicale; JPB Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut des maladies génétiques Imagine; National Center for Advancing Translational Sciences; Medical Research Council; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute; Fondazione IRCCS Policlinico San Matteo; St. Giles Foundation","keywords":"Virology; Encephalitis; Biology; Virus; Flaviviridae; Japanese encephalitis; Flavivirus; Togaviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002497809,0.000168223,0.0003089023,0.0002004041,0.0000715659,0.00001398872,0.00009598664,0.00003752068,0.0006707421],"category_scores_gemma":[0.0000508676,0.00007443069,0.0000587924,0.0004340319,0.0001902678,0.0002002881,0.00003081982,0.0003603621,0.00001534378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087471,"about_ca_system_score_gemma":0.0001144029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001658831,"about_ca_topic_score_gemma":0.00001534864,"domain_scores_codex":[0.9988548,0.00005320557,0.0003778795,0.0001134427,0.0004030762,0.000197588],"domain_scores_gemma":[0.999342,0.00007394691,0.0001052615,0.0001622676,0.00009108258,0.0002253995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08917416,0.007756156,0.5329129,0.000673037,0.002929711,0.007062205,0.05453143,0.0006363001,0.2250703,0.001185682,0.06725107,0.01081711],"study_design_scores_gemma":[0.01819619,0.02667622,0.9106693,0.007577154,0.001342747,0.001370348,0.004776627,0.0006902879,0.01206894,0.0001127039,0.01596117,0.0005582754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925403,0.00483933,0.00001839124,0.001037929,0.0008589273,0.0002396952,0.000004409708,0.0000236458,0.0004373936],"genre_scores_gemma":[0.9982915,0.0001389431,0.00004336889,0.000502463,0.0004347668,0.000002404505,0.000005689326,0.0000291027,0.0005517919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3777565,"threshold_uncertainty_score":0.7344155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635564993410748,"score_gpt":0.3259671236904907,"score_spread":0.2996114737563832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}