{"id":"W4403967384","doi":"10.1016/j.compbiomed.2024.109324","title":"Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4","year":2024,"lang":"en","type":"article","venue":"Computers in Biology and Medicine","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"","keywords":"Ototoxicity; Cisplatin; Computer science; Audiology; Machine learning; Artificial intelligence; Medicine; Psychology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00101854,0.0005759512,0.0004406031,0.0005252558,0.0001977284,0.0004194466,0.0004757269,0.0004614543,0.0015108],"category_scores_gemma":[0.002417587,0.0001740781,0.0007678706,0.0002345823,0.0002484008,0.0001921832,0.00043929,0.000841054,0.0002323182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003485129,"about_ca_system_score_gemma":0.0004590801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004201823,"about_ca_topic_score_gemma":0.002940385,"domain_scores_codex":[0.9997473,0.0001090165,0.00001055089,0.00007229623,0.00002463335,0.00003612545],"domain_scores_gemma":[0.9991521,0.0005970605,0.00009544981,0.00004138438,0.00007418088,0.00003992685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009371018,0.00035522,0.2356931,0.00006114927,0.0005366919,0.0007545899,0.00009840528,0.7018626,0.007032035,0.001999375,0.00215131,0.04851842],"study_design_scores_gemma":[0.00001448246,0.0000528694,0.01329567,0.000006957313,0.0000404358,0.00007878246,0.00001289674,0.9849163,0.0004128552,0.00100845,0.000152575,0.000007667502],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9263697,0.0004641305,0.07030059,0.0007588702,0.00004053014,0.00004375972,0.0006549399,0.0001853362,0.001182143],"genre_scores_gemma":[0.9932683,0.000102123,0.004857726,0.00008929823,0.00001661547,0.00003166143,0.0007949219,0.00001172628,0.0008277033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004201823,"threshold_uncertainty_score":0.008354723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0409778436841998,"score_gpt":0.3242608956048963,"score_spread":0.2832830519206965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}