{"id":"W4403972887","doi":"10.1101/2024.10.30.621196","title":"A novel miniaturized filamentous phagemid as a gene delivery vehicle to target mammalian cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Phagemid; Gene delivery; Gene; Computational biology; Biology; Cell biology; Genetics; Bacteriophage; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002628298,0.0003211137,0.0002149738,0.0002156379,0.0001909497,0.0003633349,0.0003515494,0.0003995959,0.0007016239],"category_scores_gemma":[0.0001140729,0.0001466423,0.0002016611,0.0001355266,0.000197449,0.0002428091,0.0002964612,0.000355298,0.0004761624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000436767,"about_ca_system_score_gemma":0.0003030361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005285325,"about_ca_topic_score_gemma":0.0005706101,"domain_scores_codex":[0.9998919,0.00001700468,0.000006637629,0.00002773547,0.00004163663,0.00001509104],"domain_scores_gemma":[0.9999449,0.00001020121,0.00001073774,0.000005534068,0.000009000034,0.00001959546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002398569,0.00001669883,0.00009208906,0.00003595336,0.000002973423,0.00005372281,0.00001202711,0.0001284352,0.9958818,0.000374656,0.0001381087,0.003239583],"study_design_scores_gemma":[0.0000160223,0.0002995598,0.0008626976,0.000007241535,0.00001376609,0.0003638978,0.00001011537,0.002214389,0.9784871,0.00009162233,0.0176231,0.0000105357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7190161,0.004281262,0.2671116,0.0004564653,0.0003284292,0.0005050297,0.001249886,0.001991379,0.005059843],"genre_scores_gemma":[0.8178898,0.002277461,0.1655561,0.0001658851,0.00006725486,0.0003119639,0.001820345,0.0001431023,0.0117681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007016239,"threshold_uncertainty_score":0.003169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878970794563679,"score_gpt":0.2602479113905176,"score_spread":0.2414582034448808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}