{"id":"W4403985390","doi":"10.1021/acs.biomac.4c01259","title":"In Situ Gelling Eye Drops of Tacrolimus with Improved Ocular Delivery and Therapeutic Efficacy","year":2024,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Barrie Urology Group","funders":"National Key Research and Development Program of China; Health Commission of Zhejiang Province; Wenzhou Municipal Science and Technology Bureau; Natural Science Foundation of Tianjin City","keywords":"Tacrolimus; In situ; Eye drop; Ophthalmology; Chemistry; Medicine; Biomedical engineering; Pharmacology; Surgery; Transplantation; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102802,0.0001585021,0.0002683252,0.0001412646,0.00002328601,0.00002996906,0.00005300933,0.00008269599,0.00001240936],"category_scores_gemma":[0.000007138073,0.000118717,0.00007241612,0.0002509272,0.00008249954,0.00004945097,0.00002704365,0.0001146421,0.00001065082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002687242,"about_ca_system_score_gemma":0.00008094587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001084589,"about_ca_topic_score_gemma":0.0000485521,"domain_scores_codex":[0.9991378,0.00002920287,0.0001962634,0.0002778278,0.0001444554,0.0002144309],"domain_scores_gemma":[0.9996173,0.00003864747,0.00003177637,0.0002040442,0.00004015191,0.00006807163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002070361,0.00009823411,0.003491812,0.0002646309,0.0002000551,0.0009617258,0.0003944674,0.000001773065,0.9841195,0.0002387905,0.000002225049,0.01001973],"study_design_scores_gemma":[0.003304957,0.001140402,0.03979461,0.001065251,0.0004364563,0.0001147612,0.0003020947,0.002437164,0.9471126,0.00017322,0.003725368,0.0003930848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678924,0.03086317,0.0003737468,0.0003006175,0.00005053673,0.000258325,0.000004647831,0.00004804739,0.0002084798],"genre_scores_gemma":[0.9985905,0.0005454253,0.0005243972,0.0001791706,0.00003195156,0.000005641377,0.000006174808,0.00003275897,0.00008396094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03700688,"threshold_uncertainty_score":0.4841138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008142009968752827,"score_gpt":0.2524858019915829,"score_spread":0.24434379202283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}