{"id":"W4403985390","doi":"10.1021/acs.biomac.4c01259","title":"In Situ Gelling Eye Drops of Tacrolimus with Improved Ocular Delivery and Therapeutic Efficacy","year":2024,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Barrie Urology Group","funders":"National Key Research and Development Program of China; Health Commission of Zhejiang Province; Wenzhou Municipal Science and Technology Bureau; Natural Science Foundation of Tianjin City","keywords":"Tacrolimus; In situ; Eye drop; Ophthalmology; Chemistry; Medicine; Biomedical engineering; Pharmacology; Surgery; Transplantation; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205973,0.0003478207,0.0002449422,0.0001467,0.0001030419,0.0002294883,0.0001404706,0.0003197345,0.0006286696],"category_scores_gemma":[0.0001070308,0.0001272573,0.0001939228,0.00008488127,0.0001215255,0.0002106554,0.0001185547,0.0003378108,0.0001331145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859525,"about_ca_system_score_gemma":0.0001153132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004485191,"about_ca_topic_score_gemma":0.0010635,"domain_scores_codex":[0.9999175,0.0000121216,0.000007439316,0.00001606486,0.00002625671,0.00002063497],"domain_scores_gemma":[0.9999298,0.00001362415,0.00002732352,0.000004723925,0.0000119999,0.00001253374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001295735,0.000006993805,0.00001303943,0.00001747167,0.000001414592,0.00001465157,0.00000427891,0.00001964053,0.9993188,0.00001198838,0.000007177528,0.0005714645],"study_design_scores_gemma":[0.000005984653,0.00018994,0.0004620601,0.000001894387,0.00001301944,0.00007719979,0.000004237061,0.0003380389,0.9982255,0.000004186193,0.0006754572,0.000002473661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878784,0.002576882,0.007790732,0.0001319408,0.00004826201,0.00004643973,0.0000979697,0.00008685157,0.0013425],"genre_scores_gemma":[0.9887605,0.001344622,0.00793407,0.0001003506,0.0000239972,0.00003072533,0.00008341026,0.00001893789,0.001703389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006286696,"threshold_uncertainty_score":0.00210315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008142009968752827,"score_gpt":0.2524858019915829,"score_spread":0.24434379202283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}