{"id":"W4404007927","doi":"10.1002/prp2.70024","title":"Identification of cytokine release syndrome and indicators of severity in retrospective databases among patients receiving immunotherapy","year":2024,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Group for Research in Decision Analysis","funders":"Ipsen; Flatiron Health; Pharmacyclics; BeiGene; Janssen Scientific Affairs; Servier; TG Therapeutics; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Retrospective cohort study; Tocilizumab; Lasso (programming language); Database; Internal medicine; Emergency medicine; Computer science; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002651147,0.0001665627,0.0004878026,0.001975834,0.00008972527,0.00002244547,0.0002036779,0.00009767473,0.001401353],"category_scores_gemma":[0.0006635059,0.0001582781,0.00008736199,0.002005808,0.001603697,0.0003302786,0.0001917304,0.001088768,0.000006519209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006626518,"about_ca_system_score_gemma":0.0003091182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004945482,"about_ca_topic_score_gemma":0.00004359592,"domain_scores_codex":[0.9968058,0.0007403943,0.0005058743,0.0006485328,0.0008377967,0.0004615725],"domain_scores_gemma":[0.9981492,0.0006948207,0.000108258,0.0003278381,0.0005709346,0.0001489121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001383468,0.0009098561,0.4782085,0.0003898289,0.0003876787,0.0001180029,0.006746517,0.000001170781,0.5065886,0.0001984265,0.0003112541,0.004756652],"study_design_scores_gemma":[0.0017729,0.000652008,0.8858163,0.0002112477,0.00003468685,0.00002027049,0.002120243,0.0002686622,0.1086246,0.000189155,0.0001831173,0.0001067262],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933927,0.003989024,0.00001205937,0.0004376515,0.0001072132,0.001263791,0.0001116949,0.00003803733,0.0006478241],"genre_scores_gemma":[0.9936094,0.005487781,0.00003922507,0.000008912403,0.00005594491,0.0001210728,0.0000236728,0.00004066983,0.0006133243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4076078,"threshold_uncertainty_score":0.9995115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03275787449147814,"score_gpt":0.4094743979644281,"score_spread":0.37671652347295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}