{"id":"W4404013086","doi":"10.1016/j.bbi.2024.11.008","title":"A microglia-containing cerebral organoid model to study early life immune challenges","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Mental Health; National Institutes of Health","keywords":"Microglia; Organoid; Immune system; Neuroscience; Medicine; Immunology; Psychology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003950516,0.000241099,0.000220874,0.0002149412,0.0004388981,0.0003442779,0.0002886389,0.00006238947,0.00008691914],"category_scores_gemma":[0.000339411,0.000233743,0.0000657265,0.0002767018,0.00004220959,0.0003466076,0.0002432458,0.0003774373,0.0001006498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965562,"about_ca_system_score_gemma":0.00006421823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002627751,"about_ca_topic_score_gemma":0.00001182349,"domain_scores_codex":[0.9981645,0.0003679525,0.0003532268,0.000552122,0.0002654367,0.0002967279],"domain_scores_gemma":[0.9991003,0.0001652352,0.00004444259,0.0004434878,0.00003712363,0.0002094297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003803557,0.0002179867,0.00009728717,0.00001239825,0.000003461017,0.00005635503,0.006318444,0.00001375009,0.9832454,0.003228392,0.00004242775,0.006726073],"study_design_scores_gemma":[0.0009154589,0.001074086,0.02858604,0.00002934407,0.00005355337,0.0000756703,0.001336965,0.002174813,0.9647141,0.0002909162,0.0002677435,0.0004813355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957093,0.0002108113,0.0002965077,0.002079799,0.000310024,0.0007922711,0.00002241289,0.0003694447,0.0002094158],"genre_scores_gemma":[0.9975846,0.0000562352,0.0001664938,0.001123974,0.00004837184,0.0001239458,0.000002480842,0.00005068256,0.0008432521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02848876,"threshold_uncertainty_score":0.9531762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08324982721949484,"score_gpt":0.3076242653515168,"score_spread":0.224374438132022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}