{"id":"W4404018080","doi":"10.1101/2024.10.31.621330","title":"Epigenetic silencing and host genome evolution determine fate of viral insertions in <i>Acanthamoeba</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Epigenetics; Biology; Gene silencing; Host (biology); Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009646922,0.0001094385,0.0001475707,0.0002471893,0.0001927614,0.000324728,0.0001255834,0.0002314162,0.0006289063],"category_scores_gemma":[0.0002149912,0.0001185933,0.0001519338,0.0001893374,0.00015316,0.0001671653,0.000189946,0.0002678924,0.0002449352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963858,"about_ca_system_score_gemma":0.0001693236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003154447,"about_ca_topic_score_gemma":0.003375757,"domain_scores_codex":[0.9999226,0.000008079387,0.000003956633,0.00002340248,0.00001700921,0.00002492564],"domain_scores_gemma":[0.9998285,0.00003889752,0.00004604737,0.00001760434,0.00003617859,0.00003274506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002977086,0.000007279102,0.004007021,0.000009421664,0.000002706461,0.00001718814,0.00003721794,0.00005196514,0.9949597,0.0000598808,0.000008081187,0.0008096411],"study_design_scores_gemma":[0.000008833309,0.0002289761,0.4602139,0.0000117395,0.00002899517,0.000352853,0.0005187281,0.004223011,0.529797,0.00030308,0.004293128,0.00001963409],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984537,0.000136273,0.0007362128,0.00001114611,0.000002064433,0.00000373529,0.0001100244,0.00002544402,0.0005213612],"genre_scores_gemma":[0.9990169,0.00004926544,0.000402084,0.00001023859,0.000001068616,0.000003914107,0.0001947269,0.00001037191,0.000311417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003154447,"threshold_uncertainty_score":0.006272197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034695532326087,"score_gpt":0.2281990360174756,"score_spread":0.2178520806942147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}