{"id":"W4404020334","doi":"10.1038/s41467-024-51719-6","title":"CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Toronto; Wellcome; Imperial College London; St. George's, University of London; Research Councils UK; Department of Health and Social Care; King's College London; UK Research and Innovation; National Institute for Health and Care Research; Sunnybrook Research Institute; Cancer Research UK; Wellcome Trust","keywords":"Innate lymphoid cell; Biology; Immunology; Innate immune system; Microbiome; Homeostasis; Inflammatory bowel disease; Gut flora; Immune system; Population; Inflammation; Acquired immune system; Immunity; Cell biology; CTLA-4; Disease; T cell; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174142,0.0001719622,0.0001198878,0.000172032,0.0001069659,0.0002610785,0.0001123442,0.000152542,0.001480811],"category_scores_gemma":[0.000108333,0.00007071219,0.0001301915,0.00008805377,0.0002120268,0.0001285227,0.000157135,0.0005005734,0.0002268341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739824,"about_ca_system_score_gemma":0.0002382464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002213638,"about_ca_topic_score_gemma":0.0004294319,"domain_scores_codex":[0.9998997,0.00002808826,0.000004808323,0.00001044106,0.0000181191,0.00003881639],"domain_scores_gemma":[0.999947,0.000006745744,0.00001469866,0.000006943303,0.000008239151,0.00001649258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000284576,0.00006328456,0.0007679142,0.00003018739,0.000004396147,0.00007131721,0.00001584764,0.00007478672,0.9949066,0.0001181916,0.00007649003,0.003586517],"study_design_scores_gemma":[0.0001950863,0.002016167,0.05112005,0.00003223638,0.00008241337,0.0007882729,0.00022314,0.003231705,0.9346234,0.0005821258,0.00709447,0.00001085886],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957437,0.001136741,0.0009127323,0.0001417492,0.00002395457,0.00001707674,0.00005860734,0.00005187443,0.001913604],"genre_scores_gemma":[0.9971245,0.0004934255,0.0004688107,0.00006957458,0.00001370688,0.00001521398,0.00005592021,0.000004951784,0.001753983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001480811,"threshold_uncertainty_score":0.004953802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551508446685353,"score_gpt":0.2679893295516553,"score_spread":0.2524742450848018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}