{"id":"W4404020334","doi":"10.1038/s41467-024-51719-6","title":"CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Toronto; Wellcome; Imperial College London; St. George's, University of London; Research Councils UK; Department of Health and Social Care; King's College London; UK Research and Innovation; National Institute for Health and Care Research; Sunnybrook Research Institute; Cancer Research UK; Wellcome Trust","keywords":"Innate lymphoid cell; Biology; Immunology; Innate immune system; Microbiome; Homeostasis; Inflammatory bowel disease; Gut flora; Immune system; Population; Inflammation; Acquired immune system; Immunity; Cell biology; CTLA-4; Disease; T cell; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003360223,0.0002650592,0.0002857308,0.0003870181,0.000381894,0.0000974524,0.001207715,0.0008187601,0.00008252041],"category_scores_gemma":[0.0000680257,0.0002483969,0.0001215395,0.0005836645,0.000251151,0.0002105611,0.0006372681,0.001769343,0.0007128999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726313,"about_ca_system_score_gemma":0.000190693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001578633,"about_ca_topic_score_gemma":0.0006219591,"domain_scores_codex":[0.99829,0.0003810789,0.0004018087,0.0004173992,0.00005070729,0.0004590102],"domain_scores_gemma":[0.9979148,0.0002673721,0.00007799173,0.001606286,0.0001018545,0.00003168136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002864729,0.0002137529,0.0002104177,0.00005326133,0.0001266864,0.00001750784,0.001641046,0.00001861932,0.9757369,0.002832389,0.01364979,0.005471034],"study_design_scores_gemma":[0.0009449512,0.0000356037,0.001226144,0.0002990427,0.00007451508,0.0001687528,0.0002930727,0.0001779469,0.3123549,0.0003903136,0.6835729,0.0004618686],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7498776,0.2228297,0.0001584235,0.003428467,0.003912829,0.0007936881,0.004915279,0.0006351081,0.01344885],"genre_scores_gemma":[0.9922148,0.003991815,0.000945633,0.0003760589,0.00003616075,0.00005142541,0.0007321385,0.00004384955,0.001608116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6699231,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551508446685353,"score_gpt":0.2679893295516553,"score_spread":0.2524742450848018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}