{"id":"W4404021236","doi":"10.1128/jvi.00832-24","title":"A temperature-sensitive and less immunogenic Sendai virus for efficient gene editing","year":2024,"lang":"en","type":"article","venue":"Journal of Virology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; European Molecular Biology Organization","keywords":"Genome editing; Biology; Sendai virus; Transduction (biophysics); CRISPR; Gene delivery; Viral vector; Stem cell; Genetic enhancement; Cas9; Hematopoietic stem cell; Computational biology; Haematopoiesis; Virology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238751,0.000287492,0.0001865695,0.0001746038,0.0001279055,0.0003550319,0.0002456614,0.000315951,0.0005594312],"category_scores_gemma":[0.00017579,0.0001200956,0.0003362569,0.00008829332,0.0002378454,0.0002387351,0.0002817559,0.0007474402,0.0002430133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485725,"about_ca_system_score_gemma":0.0002229656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002208604,"about_ca_topic_score_gemma":0.000284436,"domain_scores_codex":[0.9997631,0.00004600999,0.00002914775,0.00003905771,0.00009328088,0.00002933906],"domain_scores_gemma":[0.9998665,0.00002195259,0.0000509264,0.00002272343,0.00001840839,0.00001954559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001230236,0.000009385243,0.00006845198,0.00002397283,0.000003307355,0.0000281063,0.000007705042,0.00009600257,0.9984146,0.0002101109,0.00002994669,0.001096121],"study_design_scores_gemma":[0.000008076117,0.0001939305,0.0005620082,0.000006205001,0.00001305797,0.0003902302,0.00001518869,0.001810168,0.9929596,0.0001067515,0.003925295,0.000009663339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8559,0.002434282,0.1376392,0.0002904009,0.0001759336,0.0001893551,0.0003635485,0.0004187044,0.002588553],"genre_scores_gemma":[0.9560833,0.001047332,0.03944138,0.00009673808,0.00002301577,0.0001093939,0.0004328954,0.00005415978,0.002711784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005594312,"threshold_uncertainty_score":0.001871467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005608549423934808,"score_gpt":0.2836328603440772,"score_spread":0.2780243109201424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}