{"id":"W4404022183","doi":"10.1016/j.ebiom.2024.105413","title":"Identification of late-stage tau accumulation using plasma phospho-tau217","year":2024,"lang":"en","type":"article","venue":"EBioMedicine","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"H2020 Marie Skłodowska-Curie Actions; Fonds de Recherche du Québec - Santé; HORIZON EUROPE Framework Programme; National Institutes of Health; Olav Thon Stiftelsen; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Horizon 2020 Framework Programme; Else Kröner-Fresenius-Stiftung; University College London; Canada Foundation for Innovation; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Consortium canadien en neurodégénérescence associée au vieillissement; Horizon 2020; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Stage (stratigraphy); Identification (biology); Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196309,0.00008896145,0.00009878906,0.00008251692,0.00003824153,0.00001604694,0.0000806738,0.00008896328,0.00007028716],"category_scores_gemma":[0.00003981863,0.00007633284,0.00004960445,0.0001826305,0.00006840876,0.000005876453,0.00003497653,0.00004837349,0.00001216909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001341797,"about_ca_system_score_gemma":0.00004708962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000505856,"about_ca_topic_score_gemma":0.000005569499,"domain_scores_codex":[0.9992872,0.00001460855,0.0002438319,0.0002179989,0.0001224656,0.0001138437],"domain_scores_gemma":[0.9996325,0.000007112732,0.00006892745,0.0002033236,0.0000508117,0.00003734399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002427888,0.00002019466,0.0001975558,0.00007534714,0.00003152519,0.000004378025,0.00006835537,0.0002906666,0.9944741,0.0001525011,0.0004824519,0.00417861],"study_design_scores_gemma":[0.0003255996,0.0001455233,0.001144143,0.00008732478,0.00002884757,0.000004452943,0.00006924016,0.02711722,0.9421477,0.00006065992,0.02876311,0.000106142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892581,0.001429925,0.008352811,0.0001590393,0.000393658,0.0001364093,0.00003228169,0.00002069982,0.0002171006],"genre_scores_gemma":[0.9966827,0.00007020337,0.0002440413,0.00004306985,0.0003127892,0.000004782314,0.0001790848,0.0000171773,0.002446152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05232639,"threshold_uncertainty_score":0.3112763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857442507876201,"score_gpt":0.3278314792839175,"score_spread":0.2992570542051555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}