{"id":"W4404025318","doi":"10.1002/oby.24184","title":"Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (<scp>SYNCHRONIZE™</scp>‐1 and ‐2)","year":2024,"lang":"en","type":"article","venue":"Obesity","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"LMC Diabetes & Endocrinology (Canada); University of Calgary; McMaster University; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Boehringer Ingelheim Stiftung","keywords":"Medicine; Tolerability; Type 2 diabetes; Placebo; Obesity; Internal medicine; Clinical trial; Clinical endpoint; Randomization; Diabetes mellitus; Randomized controlled trial; Weight loss; Physical therapy; Adverse effect; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004018669,0.0001726919,0.001538052,0.0001036293,0.00004382524,0.0000233585,0.00003089256,0.00006534914,0.0000195144],"category_scores_gemma":[0.001375615,0.0001197925,0.000310878,0.00008513726,0.000198418,0.00006844174,0.00002607008,0.00002971744,0.00000280931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004408032,"about_ca_system_score_gemma":0.0001090938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000405774,"about_ca_topic_score_gemma":0.000008033139,"domain_scores_codex":[0.9981018,0.0005298875,0.0007511536,0.0003084887,0.0001553085,0.0001534014],"domain_scores_gemma":[0.9918724,0.007565271,0.0001900149,0.0001828562,0.00007906028,0.0001104148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1106656,0.03706122,0.191011,0.0089678,0.03178743,0.0002979787,0.004072086,0.00007420362,0.01690077,0.05312783,0.02851049,0.5175236],"study_design_scores_gemma":[0.8989836,0.007560672,0.007371469,0.0005463396,0.01422096,0.00001171218,0.0001488932,0.0207911,0.02931545,0.007910521,0.01294054,0.0001987583],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623882,0.008745908,0.02339753,0.0001924218,0.0001880397,0.004671434,0.00007909633,0.00004049478,0.0002969097],"genre_scores_gemma":[0.9807735,0.004894396,0.01019223,0.00005033311,0.0001930563,0.0002663825,0.0001231888,0.0000223666,0.00348451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.788318,"threshold_uncertainty_score":0.4884994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228314826761485,"score_gpt":0.4166436150841353,"score_spread":0.2938121324079868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}