{"id":"W4404029243","doi":"10.1101/2024.11.04.621834","title":"F2,6BP restores mitochondrial genome integrity in Huntington’s Disease","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Alzheimer's Association","keywords":"Mitochondrial DNA; Disease; Business; Genome; Mitochondrion; Natural resource economics; Biology; Cell biology; Medicine; Genetics; Economics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626309,0.0006041903,0.0006829785,0.0004343172,0.0002307913,0.0003157456,0.000426949,0.0006378581,0.002105008],"category_scores_gemma":[0.0001698556,0.0002111778,0.0002628125,0.0001931758,0.0002333694,0.0002161554,0.0003415326,0.0006922811,0.0004856317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552991,"about_ca_system_score_gemma":0.0001751026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091175,"about_ca_topic_score_gemma":0.0009725069,"domain_scores_codex":[0.9998853,0.00001928832,0.00001648028,0.00002626037,0.00002431394,0.00002832613],"domain_scores_gemma":[0.9998171,0.0000177163,0.00003367899,0.00001646151,0.00002162466,0.00009351966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000842188,0.0001722208,0.0001170421,0.00008330381,0.00001658617,0.0001039913,0.0000222396,0.00004708986,0.9968214,0.00005158983,0.00009729093,0.001625021],"study_design_scores_gemma":[0.0002488421,0.00291377,0.01075235,0.00003960792,0.00006868598,0.0007999646,0.00009855191,0.00103305,0.9776783,0.0001581483,0.006188163,0.00002068871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956858,0.001683639,0.00101873,0.0001273519,0.00008170066,0.00002861586,0.0006000068,0.0001831685,0.0005910254],"genre_scores_gemma":[0.9942945,0.0007860615,0.00108574,0.0000562618,0.00002229851,0.00002880527,0.001275227,0.0000353302,0.002415792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105008,"threshold_uncertainty_score":0.007041931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02647860500380591,"score_gpt":0.2528267239208646,"score_spread":0.2263481189170587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}