{"id":"W4404029679","doi":"10.1101/2024.11.03.24316667","title":"Blood DNA Methylation Signature for Incident Dementia: Evidence from Longitudinal Cohorts","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"dNaM; Dementia; Framingham Heart Study; Biomarker; DNA methylation; Cohort; Oncology; Offspring; Internal medicine; Disease; Methylation; Framingham Risk Score; Cohort study; Medicine; Psychology; Biology; Pregnancy; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0080386,0.0005211994,0.0009793101,0.001169521,0.0003833992,0.001242604,0.0006267031,0.0006193358,0.001990061],"category_scores_gemma":[0.01899555,0.0004533317,0.002589095,0.001706468,0.0006114411,0.0004843622,0.0009070111,0.0006763683,0.000196473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003251217,"about_ca_system_score_gemma":0.0007177024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003436332,"about_ca_topic_score_gemma":0.00391259,"domain_scores_codex":[0.9973968,0.001163241,0.0002084868,0.0008690265,0.0002753764,0.00008713663],"domain_scores_gemma":[0.9851503,0.008019494,0.003247587,0.002568187,0.0007005979,0.0003138845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002146858,0.00003395333,0.9291099,0.00098876,0.0287789,0.00009430527,0.0001462057,0.0007348128,0.001706507,0.000264635,0.001224304,0.03477086],"study_design_scores_gemma":[0.0001970514,0.0004697421,0.9614719,0.0004720814,0.02842729,0.0003703175,0.00009749451,0.001196666,0.001557705,0.001651188,0.004058537,0.00002992212],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8558567,0.1207945,0.009498147,0.002132246,0.000218584,0.0000562134,0.008727693,0.0002110065,0.002504909],"genre_scores_gemma":[0.9837499,0.01049285,0.002490656,0.000495848,0.0001390962,0.0000395703,0.002242745,0.00004044214,0.0003087653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0080386,"threshold_uncertainty_score":0.04251266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285624730294394,"score_gpt":0.3016491474956927,"score_spread":0.2730866744662533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}