{"id":"W4404050112","doi":"10.1042/cs20241084","title":"Endothelial cell-cardiomyocyte cross-talk: understanding bidirectional paracrine signaling in cardiovascular homeostasis and disease","year":2024,"lang":"en","type":"review","venue":"Clinical Science","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University Health Network; University of New Brunswick; Toronto General Hospital; University of Toronto; Ted Rogers Centre for Heart Research","funders":"Institute of Circulatory and Respiratory Health","keywords":"Paracrine signalling; Angiogenesis; Homeostasis; Contractility; Regeneration (biology); Autocrine signalling; Medicine; Cardiotoxicity; Ischemia; Disease; Endothelial stem cell; Biology; Cell biology; Internal medicine; Receptor; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008907401,0.001053147,0.001470895,0.002732091,0.0003400834,0.00137168,0.00120538,0.001581722,0.003192146],"category_scores_gemma":[0.0007216838,0.000336264,0.0004493253,0.002616906,0.0007363724,0.002362925,0.001174618,0.002776703,0.002940934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008548733,"about_ca_system_score_gemma":0.001250314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008848259,"about_ca_topic_score_gemma":0.00139353,"domain_scores_codex":[0.9998129,0.00003446302,0.00002665701,0.00002921003,0.00007315923,0.00002351506],"domain_scores_gemma":[0.9996678,0.0001457556,0.00003727911,0.00001100563,0.0000896521,0.00004854181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007814589,0.00006414633,0.0001209127,0.0159,0.00008078737,0.0002380768,0.00008106707,0.0004042113,0.002122216,0.008049204,0.04203512,0.9308261],"study_design_scores_gemma":[0.0000119769,0.00005904289,0.0003652753,0.002618974,0.00005954753,0.000818954,0.00004347621,0.00007139696,0.000330923,0.002785212,0.9928192,0.0000161119],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003880449,0.9987231,0.0001365789,0.0002552917,0.000226795,0.000002765626,0.000009260822,0.000006255176,0.0006011862],"genre_scores_gemma":[0.0002514659,0.9988841,0.0001516331,0.0001499391,0.0001746221,0.000004328539,0.00001590646,0.000001292726,0.0003667577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003192146,"threshold_uncertainty_score":0.01067883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1394879510003689,"score_gpt":0.4450755877066556,"score_spread":0.3055876367062866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}