{"id":"W4404059685","doi":"10.1177/23971983241278079","title":"Design of CONQUEST, a novel, randomized, placebo-controlled, Phase 2b platform clinical trial to investigate new treatments for patients with early active systemic sclerosis with interstitial lung disease","year":2024,"lang":"en","type":"article","venue":"Journal of Scleroderma and Related Disorders","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitätsspital Zürich; Universiteit Leiden; Jewish General Hospital; University of Leeds; Cleveland Clinic; University College London; Imperial College London; McGovern Medical School; Hospital for Special Surgery; Georgetown University; Università degli Studi di Firenze; Boehringer Ingelheim; Johns Hopkins University; University of Pittsburgh; Vanderbilt University; McGill University","keywords":"Interstitial lung disease; CONQUEST; Medicine; Placebo; Randomized controlled trial; Disease; Lung; Clinical trial; Internal medicine; Pathology; Alternative medicine; History","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01544856,0.003139247,0.002978742,0.0008701647,0.001048643,0.002144903,0.001376231,0.003689467,0.01441369],"category_scores_gemma":[0.008217688,0.001144279,0.001729595,0.0006411554,0.002175364,0.002505817,0.001183937,0.00396565,0.002257317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001099117,"about_ca_system_score_gemma":0.004844104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003035789,"about_ca_topic_score_gemma":0.0008468573,"domain_scores_codex":[0.9928161,0.004770757,0.0003029854,0.00103104,0.0005915766,0.0004876499],"domain_scores_gemma":[0.9967991,0.0007970418,0.0008415566,0.0003093777,0.0003598704,0.0008929663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9504555,0.01815205,0.001088214,0.001392099,0.0007368589,0.00008616869,0.000099398,0.0007213457,0.003971607,0.0013227,0.00375066,0.01822338],"study_design_scores_gemma":[0.910374,0.0828684,0.0008303376,0.0000641648,0.0002589198,0.00003117968,0.00001572702,0.0006954255,0.0004224932,0.0006123913,0.003805203,0.00002165873],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3056759,0.005834596,0.01329727,0.005534623,0.0051566,0.6434168,0.006281747,0.0006547484,0.01414763],"genre_scores_gemma":[0.2956125,0.001960147,0.03226855,0.00744784,0.002382301,0.647374,0.002628184,0.00009629391,0.01023026],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01544856,"threshold_uncertainty_score":0.08170074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366526948364876,"score_gpt":0.3029760614237857,"score_spread":0.269310791940137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}