{"id":"W4404059685","doi":"10.1177/23971983241278079","title":"Design of CONQUEST, a novel, randomized, placebo-controlled, Phase 2b platform clinical trial to investigate new treatments for patients with early active systemic sclerosis with interstitial lung disease","year":2024,"lang":"en","type":"article","venue":"Journal of Scleroderma and Related Disorders","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitätsspital Zürich; Universiteit Leiden; Jewish General Hospital; University of Leeds; Cleveland Clinic; University College London; Imperial College London; McGovern Medical School; Hospital for Special Surgery; Georgetown University; Università degli Studi di Firenze; Boehringer Ingelheim; Johns Hopkins University; University of Pittsburgh; Vanderbilt University; McGill University","keywords":"Interstitial lung disease; CONQUEST; Medicine; Placebo; Randomized controlled trial; Disease; Lung; Clinical trial; Internal medicine; Pathology; Alternative medicine; History","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000822994,0.0004328614,0.001886783,0.0004643464,0.0001154026,0.00009104081,0.000132594,0.0002564122,0.00002153235],"category_scores_gemma":[0.0004850797,0.0002339994,0.0005479208,0.0003188608,0.0003677369,0.0003914206,0.00002561791,0.0004025254,0.000002660957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229781,"about_ca_system_score_gemma":0.0009485953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004106049,"about_ca_topic_score_gemma":0.000001343271,"domain_scores_codex":[0.9965339,0.0002217946,0.001869152,0.0004342302,0.000593946,0.0003469665],"domain_scores_gemma":[0.9962537,0.001144615,0.0009547236,0.0002027313,0.0003893242,0.001054916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9751387,0.001659939,0.0008755578,0.0002515624,0.009022173,0.00003269188,0.001293325,0.0006792332,0.0002303359,0.00002637023,0.0006309813,0.01015911],"study_design_scores_gemma":[0.9522647,0.01008777,0.001354798,0.0175917,0.01201508,0.00006708232,0.0003873828,0.005832468,0.00002880248,0.0000591939,0.00001226933,0.0002987299],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745734,0.006753381,0.009558843,0.0004024699,0.0008112191,0.007732989,0.00007608766,0.00004281502,0.00004880071],"genre_scores_gemma":[0.9963411,0.002443221,0.0005568249,0.0001064406,0.0001806371,0.0001516888,0.00002902603,0.00007243304,0.0001186376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.022874,"threshold_uncertainty_score":0.954222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366526948364876,"score_gpt":0.3029760614237857,"score_spread":0.269310791940137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}