{"id":"W4404064248","doi":"10.1136/jitc-2024-sitc2024.0525","title":"525 Adenosine uptake through equilibrative nucleoside transporter-1 suppresses antitumor immunity by pyrimidine starvation","year":2024,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Nucleoside; Adenosine; Chemistry; Transporter; Pyrimidine; Starvation; Immunity; Biochemistry; Pharmacology; Biology; Immune system; Endocrinology; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002150437,0.0003222263,0.0002587876,0.0000494013,0.0001649421,0.0001717878,0.0001784053,0.000217379,0.00003952407],"category_scores_gemma":[0.0000993959,0.0002971806,0.0001078158,0.0001627696,0.0002678172,0.00007653597,0.00005866184,0.0002332917,0.00000881951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001630107,"about_ca_system_score_gemma":0.000194149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001770909,"about_ca_topic_score_gemma":0.000009380151,"domain_scores_codex":[0.9984131,0.00005840796,0.0004267256,0.0005287873,0.0002262744,0.0003467038],"domain_scores_gemma":[0.9992526,0.00002502304,0.00009296599,0.0003163108,0.00007414703,0.0002389229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005109259,0.0000587639,0.000843109,0.0002014972,0.0001499516,0.00005930205,0.0004031067,0.0001066597,0.9029167,0.0006782837,0.09438584,0.0001456362],"study_design_scores_gemma":[0.0004318506,0.0002518014,0.005409838,0.0002113744,0.0001199223,0.0001113906,0.0002239278,0.0001751989,0.8326913,0.001135992,0.1587702,0.0004672762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763967,0.01981788,0.001122381,0.001258176,0.0003137753,0.0002150855,0.0001786034,0.00009364248,0.0006037226],"genre_scores_gemma":[0.9949769,0.00104819,0.00127975,0.0004108263,0.0003711189,0.00001701057,0.0009981166,0.00005954321,0.0008385297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07022549,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291465467231523,"score_gpt":0.2452678759199089,"score_spread":0.2323532212475937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}