{"id":"W4404064319","doi":"10.1136/jitc-2024-sitc2024.0617","title":"617 Combined histone deacetylase and PD-L1 inhibition is safe and efficacious for the treatment of virus-associated cancers: results of a phase II clinical trial","year":2024,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Histone deacetylase; Histone deacetylase inhibitor; Medicine; Cancer research; Virology; Pharmacology; Chemistry; Histone; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002656172,0.001285058,0.001962774,0.0004238405,0.0004542263,0.001042793,0.0007809987,0.001697039,0.004255256],"category_scores_gemma":[0.00070964,0.0005774562,0.001416949,0.0004071196,0.001202845,0.0009951399,0.0004602287,0.002897423,0.0008856762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007642203,"about_ca_system_score_gemma":0.001499778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006265709,"about_ca_topic_score_gemma":0.001381904,"domain_scores_codex":[0.9994619,0.0002622277,0.00003303982,0.00008645101,0.00005507064,0.0001013878],"domain_scores_gemma":[0.999288,0.0001177453,0.0001303174,0.00006315028,0.00003798885,0.0003628292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8056757,0.07370234,0.002993578,0.0007149911,0.001072788,0.0002160966,0.0002065003,0.001364841,0.04054981,0.0003295337,0.002982921,0.07019091],"study_design_scores_gemma":[0.6155418,0.3751843,0.003399905,0.00003052352,0.0002901683,0.0001151538,0.00003449864,0.0007690005,0.002697983,0.0002062079,0.001708966,0.00002149217],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890483,0.002595409,0.0007207669,0.0006544676,0.0001266808,0.004233826,0.000872368,0.00009136162,0.001656905],"genre_scores_gemma":[0.9867176,0.002120069,0.0022999,0.001149994,0.0002311029,0.004047978,0.001398574,0.00003909193,0.001995676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004255256,"threshold_uncertainty_score":0.01423526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04024184745332243,"score_gpt":0.3652573165335079,"score_spread":0.3250154690801855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}