{"id":"W4404065577","doi":"10.1136/jitc-2024-sitc2024.1435","title":"1435 Therapeutic mRNA cancer vaccine for GBM reaches complete response in a preclinical model","year":2024,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Calgary; Providence Health Care","funders":"","keywords":"Cancer; Cancer vaccine; Cancer research; Messenger RNA; Medicine; Internal medicine; Biology; Immunotherapy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198041,0.0004864916,0.0004893316,0.0002821605,0.0001130317,0.0002537569,0.0002423389,0.0005254311,0.002672386],"category_scores_gemma":[0.0001121095,0.0001218261,0.0003085651,0.0001382326,0.0001707527,0.0003179641,0.0001214278,0.001229053,0.0009593552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002292089,"about_ca_system_score_gemma":0.0003191945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004583758,"about_ca_topic_score_gemma":0.0005537107,"domain_scores_codex":[0.9998654,0.00001751502,0.000009060953,0.00002422706,0.0000384329,0.00004544042],"domain_scores_gemma":[0.9999374,0.000007655208,0.00001254742,0.000006698338,0.00001402483,0.0000215912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005690185,0.0009353923,0.000126667,0.0001111907,0.00001895283,0.00004835206,0.00002755622,0.0003006372,0.9895688,0.0002476231,0.0008159395,0.007229896],"study_design_scores_gemma":[0.0001786585,0.01239477,0.001484621,0.00002375192,0.00006054903,0.0003100005,0.00003365873,0.002196845,0.974153,0.0001481702,0.009006357,0.000009662506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776641,0.003298102,0.009550806,0.000439928,0.0003887139,0.000350707,0.001612486,0.0005415197,0.006153713],"genre_scores_gemma":[0.9824106,0.002376882,0.004712587,0.0002391903,0.00006398436,0.0003977227,0.002391837,0.0000822786,0.007324987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002672386,"threshold_uncertainty_score":0.008939981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05780815849520819,"score_gpt":0.321062523140461,"score_spread":0.2632543646452528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}