{"id":"W4404067466","doi":"10.1136/jitc-2024-sitc2024.1488","title":"1488 A multicenter phase 2 trial of lifileucel plus pembrolizumab in patients with checkpoint inhibitor-naive metastatic NSCLC: updated results","year":2024,"lang":"en","type":"article","venue":"","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Oncology; Medicine; Internal medicine; Computer science; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002472019,0.001071506,0.001462448,0.0004311469,0.0003175515,0.0009955846,0.0007423264,0.001043001,0.003356817],"category_scores_gemma":[0.001101171,0.0004664666,0.001631369,0.0003839788,0.0003776518,0.0007138474,0.0002859271,0.001895337,0.0008393764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000735365,"about_ca_system_score_gemma":0.001387562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067149,"about_ca_topic_score_gemma":0.003879905,"domain_scores_codex":[0.9993591,0.0003670286,0.00003556266,0.00009185179,0.00006839934,0.00007803334],"domain_scores_gemma":[0.9992982,0.0001326849,0.0002079372,0.00004542487,0.00008560273,0.0002300114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7915847,0.01606612,0.01639139,0.001499794,0.006462407,0.0002600243,0.0001817611,0.001821497,0.02892635,0.000224846,0.01499396,0.1215871],"study_design_scores_gemma":[0.8201766,0.1343364,0.0299571,0.0001170943,0.002861256,0.0003269446,0.00005108877,0.001160275,0.002266367,0.0001913409,0.008507012,0.00004857958],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672673,0.01173212,0.0007563072,0.001888083,0.0003881079,0.004651526,0.008231593,0.0002056943,0.004879339],"genre_scores_gemma":[0.9643462,0.005071473,0.003039153,0.003062181,0.0005893034,0.004446383,0.01511318,0.00007819162,0.004253981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003356817,"threshold_uncertainty_score":0.01307338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740966404119063,"score_gpt":0.2987447312813352,"score_spread":0.2813350672401446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}