{"id":"W4404067494","doi":"10.1136/jitc-2024-sitc2024.1475","title":"1475 Combination of LND101, a healthy donor microbiome transplantation product, to doublet immunotherapy or immunotherapy combined with targeted therapy in metastatic renal cell carcinoma patients","year":2024,"lang":"en","type":"article","venue":"","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; London Health Sciences Centre; National Research Council Canada; Western University","funders":"","keywords":"Immunotherapy; Medicine; Renal cell carcinoma; Transplantation; Oncology; Adoptive immunotherapy; Colon carcinoma; Internal medicine; Cancer research; Colorectal cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007146265,0.0003011103,0.001078826,0.0002035989,0.000269362,0.0004954679,0.0002707031,0.0005539926,0.004487388],"category_scores_gemma":[0.0004419776,0.0001670655,0.0007991974,0.00022041,0.0003650646,0.0003200773,0.0002973772,0.0009900852,0.0006899958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004707062,"about_ca_system_score_gemma":0.0006827292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004885433,"about_ca_topic_score_gemma":0.001085713,"domain_scores_codex":[0.9996762,0.0001265327,0.0000289476,0.00005601816,0.00004004809,0.00007223044],"domain_scores_gemma":[0.9997005,0.00005032244,0.00004263367,0.00003995326,0.00001896677,0.0001476402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.462418,0.06883621,0.03593241,0.001348689,0.001719181,0.0009062778,0.0003423583,0.002302815,0.1235554,0.0004508975,0.00747527,0.2947127],"study_design_scores_gemma":[0.05446614,0.8519191,0.04573837,0.00008696549,0.0006923262,0.000870173,0.0001537664,0.001742921,0.03450935,0.0002189603,0.009547457,0.00005450087],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955635,0.001611017,0.0002244769,0.0001526677,0.0001562475,0.000345197,0.0004220571,0.00002740662,0.00149738],"genre_scores_gemma":[0.9969094,0.0003995252,0.0004672034,0.0003484643,0.00008276255,0.0002673109,0.0005322793,0.000006792909,0.0009863172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004487388,"threshold_uncertainty_score":0.01501185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450159515735894,"score_gpt":0.2636816590910579,"score_spread":0.249180063933699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}