{"id":"W4404067889","doi":"10.1172/jci.insight.178159","title":"All-in-one AAV-mediated Nrl gene inactivation rescues retinal degeneration in Pde6a mice","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; School of Medicine, Stanford University; National Institutes of Health; Stanford Bio-X; Children's Health Research Institute; International Retinal Research Foundation; U.S. Department of Veterans Affairs","keywords":"Retinal degeneration; Degeneration (medical); Retinal; Gene; Cell biology; Macular degeneration; Chemistry; Cancer research; Biology; Molecular biology; Medicine; Genetics; Pathology; Ophthalmology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003786386,0.0007480291,0.0004642668,0.0006524156,0.0002425719,0.0003625033,0.0005203355,0.0008077095,0.002013891],"category_scores_gemma":[0.000178662,0.0003577645,0.0006597023,0.0001357526,0.0004803195,0.0003336905,0.0002842062,0.001230787,0.0008835429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003883081,"about_ca_system_score_gemma":0.000301378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032529,"about_ca_topic_score_gemma":0.002004626,"domain_scores_codex":[0.9995729,0.0000442672,0.00006943649,0.0001320743,0.0001241143,0.00005704956],"domain_scores_gemma":[0.9997038,0.00004022649,0.0001128676,0.0000330543,0.00002130608,0.00008872641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003105196,0.0000245346,0.00005244451,0.00002394156,0.000004373572,0.00006926783,0.00001392555,0.00005753891,0.9987553,0.0001318636,0.00003941571,0.0007962311],"study_design_scores_gemma":[0.0000416495,0.0002366607,0.001579214,0.00001572132,0.0000287885,0.0006040692,0.00002403872,0.00171634,0.9920765,0.0001110143,0.003556162,0.000009930384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9469206,0.001926788,0.04030114,0.000619183,0.0002116034,0.0001815941,0.00239734,0.001785779,0.005655944],"genre_scores_gemma":[0.9560252,0.001575979,0.02529606,0.0002187768,0.00004086001,0.0001291678,0.001473903,0.000469092,0.01477098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013891,"threshold_uncertainty_score":0.006737113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02352177956252525,"score_gpt":0.2695196453096453,"score_spread":0.24599786574712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}