{"id":"W4404070167","doi":"10.1038/s41467-024-53837-7","title":"Inhibition of GPX4 enhances CDK4/6 inhibitor and endocrine therapy activity in breast cancer","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Imperial College London; Cancer Research UK","keywords":"Endocrine system; Palbociclib; Cancer; Breast cancer; Cancer research; Oncology; Medicine; Internal medicine; Bioinformatics; Hormone; Biology; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033277,0.0001202625,0.0002131379,0.0001792695,0.00005393526,0.00001442512,0.0001248771,0.0001143459,0.00005326162],"category_scores_gemma":[0.00001793011,0.0001014075,0.00004572007,0.0004667433,0.0002220875,0.0002190962,0.00009146591,0.0007558503,0.000001780384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001116928,"about_ca_system_score_gemma":0.000118745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001333401,"about_ca_topic_score_gemma":0.0004494636,"domain_scores_codex":[0.9993073,0.00006143072,0.0001742237,0.0001851425,0.0001425136,0.0001293754],"domain_scores_gemma":[0.999027,0.0001681296,0.00005579067,0.0005981542,0.0001070089,0.00004395221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004089324,0.000366093,0.01357396,0.0001914045,0.0001191063,0.000007216262,0.001208538,0.000003540047,0.7230489,0.003096412,0.0002323884,0.2577435],"study_design_scores_gemma":[0.003518544,0.0001936784,0.5438137,0.002866368,0.00008833859,0.0002886546,0.0005268974,0.0007426353,0.3608696,0.002124366,0.0845205,0.0004466843],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8686094,0.1051822,0.00004336465,0.02472964,0.0001477349,0.0003578049,0.0001283564,0.00008595145,0.0007155188],"genre_scores_gemma":[0.980243,0.01822465,0.0009384686,0.0002563043,0.0001031341,0.0001213431,0.00002295292,0.00002032329,0.00006983891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5302398,"threshold_uncertainty_score":0.4135276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184425483649374,"score_gpt":0.3512481833683104,"score_spread":0.332805635003373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}