{"id":"W4404070910","doi":"10.3390/vetsci11110540","title":"Longitudinal Study of Transcriptomic Changes Occurring over Six Weeks of CHOP Treatment in Canine Lymphoma Identifies Prognostic Subtypes","year":2024,"lang":"en","type":"article","venue":"Veterinary Sciences","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ontario Centres of Excellence","keywords":"CHOP; Lymphoma; Transcriptome; Gene; Biology; Canine Lymphoma; Internal medicine; Chemotherapy; Oncology; Gene expression; Immunology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147945,0.000106467,0.000136768,0.0001585084,0.00003654623,0.00002167607,0.000122858,0.00004398267,0.00001336843],"category_scores_gemma":[0.00001049874,0.00008956184,0.00004016608,0.0003000234,0.000141492,0.00001215168,0.00003691471,0.00001710761,6.609503e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003437457,"about_ca_system_score_gemma":0.00009462437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008869052,"about_ca_topic_score_gemma":0.003145947,"domain_scores_codex":[0.9991778,0.00004107061,0.0001816258,0.0003158355,0.0001452022,0.0001384349],"domain_scores_gemma":[0.9997681,0.00001686592,0.00005113032,0.0001227161,0.00002052943,0.0000206632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001254783,0.0002864437,0.1463998,0.0001068603,0.00007037169,0.00002039587,0.001283248,0.0009375979,0.844421,0.000008668173,0.00001744505,0.006322645],"study_design_scores_gemma":[0.0008987943,0.01196339,0.8697701,0.0002102266,0.00006365446,0.00005248113,0.001010915,0.001460916,0.1137919,0.0000178739,0.0005556957,0.0002040037],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995838,0.003470859,0.000009402664,0.00002926847,0.0003195353,0.000269496,0.00001443339,0.000008315824,0.00004064481],"genre_scores_gemma":[0.9996909,0.0001132259,0.0000247952,0.000002107219,0.00005307258,0.00002945653,0.000006052994,0.000006436032,0.0000739829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7306291,"threshold_uncertainty_score":0.3652226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03892918772139458,"score_gpt":0.3158960228091031,"score_spread":0.2769668350877085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}