{"id":"W4404073899","doi":"10.1038/s41417-024-00847-8","title":"Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma","year":2024,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Agency for Medical Research and Development; RIKEN; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Paul Scherrer Institut","keywords":"H3K4me3; Demethylase; Chromatin immunoprecipitation; Biology; Epigenetics; Histone; Cancer research; Glioma; Histone H3; Histone methylation; Epigenetic therapy; EZH2; Molecular biology; DNA methylation; Gene expression; Biochemistry; Gene; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183303,0.0001577672,0.0001423734,0.00007436488,0.00005565588,0.00002784088,0.00009381543,0.0001264365,0.00009921414],"category_scores_gemma":[0.000004753838,0.000140204,0.0001646603,0.0001515208,0.00006163101,0.000004944533,0.00002073924,0.00005575899,0.000003876562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002476898,"about_ca_system_score_gemma":0.0001228079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001094657,"about_ca_topic_score_gemma":0.000005028985,"domain_scores_codex":[0.9990931,0.00003421454,0.0002224244,0.000344741,0.0001165064,0.000189073],"domain_scores_gemma":[0.9995541,0.00001747988,0.00007199295,0.0001727705,0.0001347263,0.00004895729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005572788,0.00006898693,0.00001164768,0.0000249849,0.0001346915,0.000001305773,0.00004771518,0.0008159974,0.9123563,0.00009869668,0.0002402585,0.08564213],"study_design_scores_gemma":[0.001045497,0.0008281058,0.0001029139,0.000012929,0.00003161055,0.000002847348,0.00001310457,0.0005416629,0.9325298,0.0007682543,0.063967,0.0001562631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8172755,0.1107764,0.0706739,0.0002018979,0.0005483477,0.0003659103,0.00009613391,0.0000199181,0.00004199816],"genre_scores_gemma":[0.9747137,0.02290606,0.0008664354,0.0002306112,0.0007769618,0.0001853634,0.00008987745,0.00004018767,0.0001908427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1574381,"threshold_uncertainty_score":0.5717352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904303235812649,"score_gpt":0.3261390349018378,"score_spread":0.2970960025437113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}