{"id":"W4404073942","doi":"10.1038/s41525-024-00443-7","title":"Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients","year":2024,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Children's Hospital of Eastern Ontario; Centre Hospitalier Universitaire Sainte-Justine; London Health Sciences Centre; Alberta Children's Hospital; Hospital for Sick Children; University of British Columbia; Stollery Children's Hospital; BC Children's Hospital; Health Sciences Centre","funders":"Canadian Institutes of Health Research; Health Canada; University of British Columbia; Centers for Disease Control and Prevention; Genome British Columbia; BC Children’s Hospital Foundation; Michael Smith Health Research BC; BC Children's Hospital; Provincial Health Services Authority; Genome Canada; International Association for the Study of Pain; Government of Canada; Children's Hospital Foundation; U.S. Department of Health and Human Services","keywords":"Peripheral neuropathy; Medicine; Vincristine; Cancer; Internal medicine; Oncology; Genetics; Bioinformatics; Chemotherapy; Biology; Endocrinology; Diabetes mellitus; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002317755,0.0002217511,0.0003612852,0.0003098825,0.00009306756,0.00001402431,0.00004716959,0.00009556307,0.0002681786],"category_scores_gemma":[0.00009744845,0.0001649706,0.00003258439,0.0004571382,0.00005211705,0.00005255402,0.00002533172,0.000409604,0.00001345674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007064934,"about_ca_system_score_gemma":0.0002815932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163035,"about_ca_topic_score_gemma":0.000809875,"domain_scores_codex":[0.9986767,0.0001163776,0.0003351561,0.0004216345,0.0001783053,0.0002718707],"domain_scores_gemma":[0.9994536,0.0000874645,0.0001186735,0.000121391,0.00007579256,0.0001431011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007614989,0.0004311209,0.9226876,0.0002530666,0.0002923502,0.0002146461,0.003419833,0.00008827905,0.04866736,0.00001351228,0.001438072,0.0217326],"study_design_scores_gemma":[0.006933193,0.001742123,0.9844787,0.0001652441,0.0008747932,0.00001451411,0.00003721564,0.004282486,0.00006080742,0.00002193125,0.001217007,0.0001719675],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940337,0.002169568,0.00004800865,0.001072237,0.0007744454,0.00107712,0.00004078283,0.00009443855,0.0006896784],"genre_scores_gemma":[0.9959119,0.001846346,0.00002396283,0.0003775705,0.0009528603,0.0002119332,0.0000913443,0.00004741596,0.0005366996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06179106,"threshold_uncertainty_score":0.6727304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875005874313386,"score_gpt":0.2804304061402275,"score_spread":0.2616803473970936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}