{"id":"W4404100045","doi":"10.1183/13993003.congress-2024.pa2980","title":"APATURA: a Phase 2a study of elarekibep, an inhaled IL-4 receptor alpha inhibitor, in moderate-to-severe asthma","year":2024,"lang":"en","type":"article","venue":"","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Asthma; Alpha (finance); Medicine; Pharmacology; Internal medicine; Anesthesia; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002385993,0.001797768,0.002195708,0.0004563737,0.0004677389,0.001524465,0.001257377,0.00211447,0.007845297],"category_scores_gemma":[0.001059895,0.0007070157,0.002101311,0.0003252361,0.0007198433,0.0009960894,0.0004635871,0.004404997,0.00184619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000614887,"about_ca_system_score_gemma":0.001686674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008823441,"about_ca_topic_score_gemma":0.00232808,"domain_scores_codex":[0.9994425,0.000243113,0.0000287602,0.0001034329,0.00007350699,0.0001086837],"domain_scores_gemma":[0.9993999,0.00007408388,0.0001103387,0.00006735636,0.00006372485,0.0002846327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6418119,0.1048084,0.003218718,0.00267621,0.002961937,0.0004733545,0.0002623938,0.001416902,0.08970264,0.0006324921,0.01827598,0.1337592],"study_design_scores_gemma":[0.7530381,0.2284905,0.006501035,0.00009042404,0.000700234,0.0004231363,0.00004683091,0.0006436234,0.003180857,0.0002595523,0.006583827,0.00004190896],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531504,0.01357839,0.002754592,0.003393398,0.001037948,0.01270779,0.006430136,0.0007877274,0.006159666],"genre_scores_gemma":[0.9241518,0.01410471,0.008794787,0.009843272,0.001154657,0.01478922,0.01335399,0.0002511585,0.01355645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007845297,"threshold_uncertainty_score":0.02624506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870702754982746,"score_gpt":0.3231341645908591,"score_spread":0.3044271370410316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}