{"id":"W4404103178","doi":"10.1101/2024.10.29.24316289","title":"Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer’s disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre; University of British Columbia; McGill University","funders":"National Health and Medical Research Council; Genentech; National Institutes of Health; Fondation pour la Recherche sur Alzheimer; Deutsches Zentrum für Neurodegenerative Erkrankungen; Bayer Vital; Fondation Brain Canada; Neuroscience Research Australia; Canadian Institutes of Health Research; Parkinson Canada; Weston Brain Institute; Japan Agency for Medical Research and Development; Biogen; Eli Lilly and Company; Alzheimer Society; Teva Pharmaceutical Industries; Novo Nordisk; Eisai; Alzheimer's Association","keywords":"Dementia; Amyloid (mycology); Disease; Medicine; Alzheimer's disease; Term (time); Amyloid β; Gerontology; Neuroscience; Psychology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004515623,0.001651375,0.002361818,0.0003646836,0.0004894987,0.0009386176,0.0009132022,0.002267568,0.003597658],"category_scores_gemma":[0.002514106,0.0005169981,0.002131857,0.0003035268,0.001150998,0.00134217,0.0005274626,0.003018727,0.0006714308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008051524,"about_ca_system_score_gemma":0.001276998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006861351,"about_ca_topic_score_gemma":0.001504522,"domain_scores_codex":[0.9987142,0.0007863439,0.00006716632,0.0001616568,0.00009923019,0.0001715092],"domain_scores_gemma":[0.9978359,0.0005375392,0.0005828848,0.0002405838,0.0002538724,0.0005492359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9717999,0.008263512,0.0007641009,0.000345354,0.0004551464,0.00004109326,0.00007819898,0.0001643929,0.004996268,0.00005937762,0.0005211995,0.01251143],"study_design_scores_gemma":[0.8642661,0.1294553,0.004162262,0.00003099348,0.0002979389,0.0000553243,0.00002131529,0.0001963446,0.0006708231,0.0001196502,0.0007078571,0.00001617743],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912049,0.002818712,0.0004422383,0.0003754784,0.0001980179,0.002698855,0.000846116,0.00006783833,0.001347897],"genre_scores_gemma":[0.9882068,0.001368457,0.00144707,0.0008313939,0.0003322429,0.00447176,0.001216636,0.0000201796,0.002105471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004515623,"threshold_uncertainty_score":0.02388114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1102476886296269,"score_gpt":0.4048141279076531,"score_spread":0.2945664392780262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}