{"id":"W4404105274","doi":"10.1101/2024.11.03.621741","title":"FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"RAD51; Homologous recombination; Recombination; Homologous chromosome; Cell biology; Chemistry; Molecular biology; Genetics; Biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009101297,0.0002322889,0.000183549,0.0001880881,0.0001245689,0.0002645479,0.000223329,0.0002015194,0.001629607],"category_scores_gemma":[0.00008916277,0.0001214285,0.0001531389,0.00008918275,0.0001322272,0.00007790476,0.0001718066,0.0003258562,0.0007973015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002987318,"about_ca_system_score_gemma":0.0001503647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005902777,"about_ca_topic_score_gemma":0.000777606,"domain_scores_codex":[0.9999256,0.00001241141,0.000006293367,0.00001366864,0.00002160565,0.00002037554],"domain_scores_gemma":[0.9999224,0.00001601978,0.00002392788,0.00001064351,0.000004955185,0.00002192145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004442666,0.00001617258,0.0001023606,0.00001411309,0.000001876852,0.00002024142,0.000003709582,0.00004770478,0.9991761,0.00004767685,0.00004991219,0.000475601],"study_design_scores_gemma":[0.000009406799,0.00005849882,0.001917149,0.000003637195,0.000002662613,0.0000971126,0.000006634422,0.0005935704,0.9952239,0.00001664954,0.002069516,0.000001340154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926473,0.001418199,0.002178383,0.00012608,0.00002460163,0.00001869194,0.0006023647,0.0001635729,0.002820866],"genre_scores_gemma":[0.9916392,0.0004644475,0.002006806,0.00006438063,0.000009456778,0.00002857342,0.001344628,0.00005131218,0.004391258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629607,"threshold_uncertainty_score":0.00545162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006410852842656061,"score_gpt":0.2105444499812403,"score_spread":0.2041335971385843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}