{"id":"W4404105468","doi":"10.1038/s41409-024-02447-4","title":"Measurable residual mutated IDH1 before allogeneic transplant for acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Navy; Health Resources and Services Administration; Syndax Pharmaceuticals; Office of Naval Research; Jazz Pharmaceuticals; Genentech; AstraZeneca; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health; Amgen; Gilead Sciences; U.S. Department of Defense","keywords":"NPM1; IDH1; Medicine; Myeloid leukemia; Internal medicine; Oncology; Minimal residual disease; IDH2; Transplantation; Hematopoietic stem cell transplantation; Leukemia; Myeloid; Mutation; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007072168,0.0004080145,0.0005469816,0.0004800431,0.0002118592,0.0001145483,0.0001824681,0.0003336663,0.0001665185],"category_scores_gemma":[0.00002670724,0.0003574326,0.0002897999,0.000577922,0.0001232366,0.0003238545,0.000009466302,0.0005286976,0.0001540357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007731265,"about_ca_system_score_gemma":0.001206409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001938686,"about_ca_topic_score_gemma":0.000275118,"domain_scores_codex":[0.9969824,0.00009537641,0.000627575,0.0007644775,0.0007404585,0.0007897075],"domain_scores_gemma":[0.998877,0.0002054432,0.00005816243,0.0003517947,0.0002043347,0.00030319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007753089,0.00009960149,0.00108863,0.004195516,0.001612573,0.005001881,0.004279847,0.0001947522,0.9427323,0.001270905,0.008687555,0.02308337],"study_design_scores_gemma":[0.0244342,0.00414125,0.02592309,0.00396407,0.01150176,0.01672942,0.0005157151,0.02971402,0.8554897,0.003069784,0.02236086,0.002156091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698476,0.001547605,0.01715145,0.003898691,0.0005026149,0.002586572,0.001697593,0.0008186704,0.001949239],"genre_scores_gemma":[0.9833778,0.001710706,0.003871719,0.0003504739,0.0004121488,0.00043472,0.005160741,0.0001592494,0.004522515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08724254,"threshold_uncertainty_score":0.9998878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979265900489028,"score_gpt":0.2970428500041754,"score_spread":0.2772501909992851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}