{"id":"W4404107499","doi":"10.1016/j.molcel.2024.10.016","title":"Profound synthetic lethality between SMARCAL1 and FANCM","year":2024,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Lethality; Synthetic lethality; Cell biology; Genetics; DNA repair; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004952835,0.001010566,0.0004384121,0.001012736,0.0003678891,0.0004978129,0.0006740807,0.0008886983,0.004427155],"category_scores_gemma":[0.0003704878,0.0003371678,0.0004498908,0.0003884312,0.000681263,0.0002855367,0.0007031029,0.001088645,0.0008885188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006514169,"about_ca_system_score_gemma":0.0004516244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001240036,"about_ca_topic_score_gemma":0.001156224,"domain_scores_codex":[0.9993829,0.0001521015,0.00006624719,0.0001246661,0.0001664721,0.0001077328],"domain_scores_gemma":[0.9994748,0.0001768504,0.0000986217,0.00008851814,0.00002138402,0.0001398716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003288416,0.00003792142,0.0002172822,0.00003173546,0.00002106929,0.0003117629,0.00001759096,0.0005206452,0.9957408,0.001165313,0.0001883576,0.001418815],"study_design_scores_gemma":[0.00003596706,0.0001352741,0.001440633,0.000005669348,0.00001445831,0.0008061347,0.0000300298,0.001653602,0.9923319,0.0001368398,0.00339826,0.00001133118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778382,0.001144412,0.01070077,0.0004125699,0.0001882784,0.00009447012,0.003151738,0.0006834881,0.005786034],"genre_scores_gemma":[0.9929438,0.0002021801,0.002252588,0.00007009081,0.0000148893,0.00005652229,0.0009873474,0.0000999439,0.003372557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004427155,"threshold_uncertainty_score":0.01481032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008678169778705157,"score_gpt":0.2547585106345419,"score_spread":0.2460803408558367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}