{"id":"W4404107499","doi":"10.1016/j.molcel.2024.10.016","title":"Profound synthetic lethality between SMARCAL1 and FANCM","year":2024,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Lethality; Synthetic lethality; Cell biology; Genetics; DNA repair; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594192,0.0001369656,0.000111821,0.00002514406,0.00004376009,0.00006301061,0.00009755001,0.0001206594,0.00002307128],"category_scores_gemma":[0.00002321038,0.0001282305,0.0000783544,0.00005972529,0.00006611447,0.000001984144,0.00009229862,0.0001041009,0.00002396692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001291007,"about_ca_system_score_gemma":0.00006990122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000218388,"about_ca_topic_score_gemma":0.000002951335,"domain_scores_codex":[0.9991062,0.00004882623,0.0001363331,0.0004012461,0.0001139771,0.0001933911],"domain_scores_gemma":[0.9995657,0.00001025976,0.00001867998,0.0002848998,0.00002316695,0.00009734456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008503136,0.00001913708,0.0004435158,0.0002701256,0.00005346642,0.00003236375,0.00005492708,0.00003839416,0.9818304,0.0001349585,0.0008905595,0.0162236],"study_design_scores_gemma":[0.0002843732,0.0001491866,0.0004246178,0.00007975505,0.00008838544,0.00002182324,0.00002933674,0.0007357017,0.8682284,0.0009698509,0.1286118,0.0003767344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743917,0.01022907,0.00874496,0.000245856,0.0001219553,0.0001296725,0.00001811253,0.00003847291,0.006080231],"genre_scores_gemma":[0.9977182,0.0001300679,0.0006170758,0.0001665239,0.0001467726,0.00001393556,0.00005254688,0.00003162732,0.001123309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1277213,"threshold_uncertainty_score":0.5229089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008678169778705157,"score_gpt":0.2547585106345419,"score_spread":0.2460803408558367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}