{"id":"W4404108697","doi":"10.1038/s41467-024-52472-6","title":"A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University of Toronto","funders":"Instituto de Salud Carlos III; Cancer Council Queensland; Medical Research Council; Rosetrees Trust; National Institutes of Health; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Sigrid Juséliuksen Säätiö; Queensland Government; U.S. Department of Defense; Umeå Universitet; National Institute for Health and Care Research; Magnus Ehrnroothin Säätiö; Cancerfonden; Fundación Mutua Madrileña; Prostate Cancer Foundation of Australia; Royal Marsden NHS Foundation Trust; Advance Queensland; Prostate Cancer Foundation; Australian Prostate Cancer Research; Movember Foundation; National Health and Medical Research Council; Cancer Research UK; Mater Foundation; Vetenskapsrådet; Australian Government; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse","keywords":"Prostate cancer; SNP; Outcome (game theory); Function (biology); Cancer; Prostate; Oncology; Medicine; Biology; Internal medicine; Bioinformatics; Single-nucleotide polymorphism; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357118,0.0002557912,0.0002605784,0.0003383826,0.0003016536,0.0003408949,0.0002145139,0.0003900533,0.002076162],"category_scores_gemma":[0.001031037,0.0001358222,0.0003141937,0.000653256,0.0002399583,0.0001285848,0.0002516549,0.0004103706,0.0002266247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011584,"about_ca_system_score_gemma":0.000177305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001660197,"about_ca_topic_score_gemma":0.001538279,"domain_scores_codex":[0.9998349,0.00004763242,0.00001322389,0.00004747179,0.00003042068,0.0000263202],"domain_scores_gemma":[0.9993941,0.0001094423,0.0002693784,0.00004918389,0.00003413275,0.000143863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007315995,0.00003945016,0.9922341,0.00001851879,0.0001421159,0.0003014283,0.00005625375,0.0001259321,0.003566535,0.00003996447,0.0001436656,0.002600296],"study_design_scores_gemma":[0.000008493779,0.0001148109,0.9987893,0.000002829871,0.00005055229,0.0004482375,0.00002818902,0.0001462824,0.0002194671,0.00006153619,0.0001274147,0.000002959464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998667,0.0005010449,0.0001376697,0.00007255617,0.00001338401,0.000003234014,0.0001966204,0.000009310466,0.0003992138],"genre_scores_gemma":[0.9996603,0.00005022586,0.00003597157,0.00001551072,0.00001097038,0.000001740592,0.00008532348,0.00000154445,0.00013843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002076162,"threshold_uncertainty_score":0.006945431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05414978222780471,"score_gpt":0.4199889258446361,"score_spread":0.3658391436168314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}