{"id":"W4404110331","doi":"10.1093/neuonc/noae236","title":"Validation and next-generation update of a DNA methylation–based recurrence predictor for meningioma: A multicenter prospective study","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Center for Biomedical Informatics and Information Technology, National Cancer Institute; Canadian Institutes of Health Research; University of Pennsylvania; Deutschen Konsortium für Translationale Krebsforschung; Freie Universität Berlin; National Cancer Institute; Humboldt-Universität zu Berlin; Deutsches Krebsforschungszentrum; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Pennsylvania State University; Vanderbilt University; Vanderbilt University Medical Center","keywords":"Meningioma; DNA methylation; Methylation; Medicine; Oncology; Internal medicine; Computational biology; DNA; Biology; Genetics; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008071695,0.0007914527,0.0004742413,0.000455505,0.000398697,0.0007438383,0.0009016118,0.0005440973,0.0006961789],"category_scores_gemma":[0.008740033,0.0003884601,0.0009953841,0.0004969623,0.0002277172,0.0004717487,0.0006927674,0.0007737074,0.0004129524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005257682,"about_ca_system_score_gemma":0.0009794761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003265721,"about_ca_topic_score_gemma":0.004060155,"domain_scores_codex":[0.9984932,0.0007896474,0.00007286241,0.0003716438,0.0001953312,0.00007727509],"domain_scores_gemma":[0.9956341,0.001320031,0.0006604375,0.001257207,0.0008541017,0.0002741504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001081463,0.0002065494,0.9766516,0.00003508703,0.0005182756,0.00009586513,0.00010519,0.003253232,0.002036316,0.00009657114,0.0007271207,0.01519278],"study_design_scores_gemma":[0.0004592225,0.003299733,0.8678755,0.00005837718,0.001986426,0.001348388,0.000198484,0.1075602,0.009685026,0.0007029197,0.006732968,0.00009293786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838464,0.0005081206,0.0129777,0.0002050433,0.0000308247,0.00008730696,0.001917843,0.0000871351,0.0003396862],"genre_scores_gemma":[0.986864,0.0001834003,0.008690351,0.0001005078,0.00003597215,0.00008908007,0.003776877,0.00003284481,0.0002269082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008071695,"threshold_uncertainty_score":0.04268771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06262276848569368,"score_gpt":0.3403999430935071,"score_spread":0.2777771746078134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}