{"id":"W4404110331","doi":"10.1093/neuonc/noae236","title":"Validation and next-generation update of a DNA methylation–based recurrence predictor for meningioma: A multicenter prospective study","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Center for Biomedical Informatics and Information Technology, National Cancer Institute; Canadian Institutes of Health Research; University of Pennsylvania; Deutschen Konsortium für Translationale Krebsforschung; Freie Universität Berlin; National Cancer Institute; Humboldt-Universität zu Berlin; Deutsches Krebsforschungszentrum; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Pennsylvania State University; Vanderbilt University; Vanderbilt University Medical Center","keywords":"Meningioma; DNA methylation; Methylation; Medicine; Oncology; Internal medicine; Computational biology; DNA; Biology; Genetics; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004635562,0.0001324684,0.0002816571,0.0002316547,0.00006324671,0.00003912803,0.00004940857,0.0000679042,0.00003132372],"category_scores_gemma":[0.0002709483,0.000115096,0.00005816777,0.0002175291,0.00004604154,0.0001559302,0.00003823909,0.000105943,0.00000454608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001036321,"about_ca_system_score_gemma":0.0001212809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004226154,"about_ca_topic_score_gemma":0.000002830211,"domain_scores_codex":[0.9987226,0.0001496933,0.0003679064,0.0004183229,0.0001888487,0.0001526586],"domain_scores_gemma":[0.9992159,0.0002771807,0.0001151688,0.0001667766,0.0001578178,0.00006717906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001112659,0.0008931368,0.007225404,0.0004054042,0.0002578507,0.0002186681,0.004626371,0.00005305232,0.9665282,0.001215819,0.001634232,0.01582921],"study_design_scores_gemma":[0.01972627,0.02697207,0.02382191,0.0002727045,0.002950237,0.0001733598,0.001401003,0.4588245,0.4219379,0.0005635862,0.04277316,0.0005833075],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867286,0.0001966529,0.007648346,0.001470624,0.0006165653,0.002964773,0.00001825042,0.00007522501,0.0002809367],"genre_scores_gemma":[0.9953504,0.000004058235,0.003767338,0.00009469657,0.0001833018,0.0004733015,0.0000737997,0.00001750591,0.00003564404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5445903,"threshold_uncertainty_score":0.4693477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06262276848569368,"score_gpt":0.3403999430935071,"score_spread":0.2777771746078134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}