{"id":"W4404112357","doi":"10.1002/anie.202412786","title":"Thieno[3,2‐<i>b</i>]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Framework Programme; Deutschen Konsortium für Translationale Krebsforschung; Masarykova Univerzita; Ministerstvo Zdravotnictví Ceské Republiky; Grantová Agentura České Republiky; European Federation of Pharmaceutical Industries and Associations; Genome Canada; McGill University; Ministerstvo Školství, Mládeže a Tělovýchovy; Bayer; European Commission; Genentech; Deutsche Krebshilfe; Bader Philanthropies; Pfizer; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Kinome; Pharmacophore; Kinase; Chemistry; Context (archaeology); Protein kinase A; Scaffold protein; Biochemistry; Stereochemistry; Biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001020009,0.0002741644,0.0001943951,0.0001483564,0.0001256545,0.0001680977,0.0002868371,0.0002158578,0.001443038],"category_scores_gemma":[0.00006701257,0.0001026855,0.0001050366,0.0001746023,0.0001652456,0.0002243689,0.0002313593,0.0004097807,0.0004266883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002170025,"about_ca_system_score_gemma":0.0002229032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006075103,"about_ca_topic_score_gemma":0.001205977,"domain_scores_codex":[0.9999592,0.000007442934,0.000002037639,0.000009455669,0.000009602687,0.00001219735],"domain_scores_gemma":[0.9999815,0.000002476236,0.00000564757,0.000002082636,0.000002673071,0.000005633799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002861719,0.00008644416,0.0001796159,0.0004275868,0.00001876191,0.0003121098,0.00007442365,0.002367109,0.9679645,0.005315738,0.0009766123,0.02199093],"study_design_scores_gemma":[0.0001333,0.001901923,0.001808354,0.00004444735,0.00002952241,0.0009788261,0.00006047198,0.005240378,0.9454969,0.0009366248,0.04332474,0.00004448802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8721591,0.0390919,0.05075987,0.000698242,0.0002496028,0.0001906137,0.001105596,0.0005583569,0.03518663],"genre_scores_gemma":[0.9724658,0.01136571,0.009719999,0.0001709664,0.00002662389,0.00007469191,0.0003825232,0.00002378811,0.005769746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443038,"threshold_uncertainty_score":0.00482744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270903462303634,"score_gpt":0.2606227510727103,"score_spread":0.247913716449674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}