{"id":"W4404115229","doi":"10.26434/chemrxiv-2024-kcjhb","title":"Metabolomics to Assess Treatment Responses to a Single Large Bolus of Enteral Cholecalciferol in Vitamin D Deficient Critically Ill Children: Insights for Precision Nutrition","year":2024,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Clinical Nutrition and Gastroenterology","field":"Nursing","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Critically ill; Cholecalciferol; Enteral administration; Parenteral nutrition; Bolus (digestion); Medicine; Vitamin D and neurology; Vitamin; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001878474,0.000549092,0.0008084807,0.001353032,0.0001862204,0.0009133837,0.0002875543,0.0004711045,0.0004898935],"category_scores_gemma":[0.002616626,0.0001892392,0.000503764,0.001204754,0.0003355072,0.0003334266,0.0004468995,0.0004458351,0.0001191358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003241845,"about_ca_system_score_gemma":0.0003868939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118559,"about_ca_topic_score_gemma":0.002016554,"domain_scores_codex":[0.9990594,0.0003506093,0.00009742608,0.000238595,0.0001984628,0.00005553384],"domain_scores_gemma":[0.9987631,0.0003910126,0.0004826228,0.0001427249,0.0001605534,0.0000600571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.005152012,0.0002292763,0.7866088,0.0006551931,0.001512191,0.0003012581,0.0003427709,0.001821839,0.1144797,0.0003110078,0.0006410987,0.08794483],"study_design_scores_gemma":[0.0001036019,0.001358888,0.9583212,0.0000672229,0.0005512543,0.0007919476,0.0003025926,0.005917023,0.02975146,0.0005000289,0.002293715,0.00004101415],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702059,0.009571925,0.01574172,0.0003453718,0.00004653544,0.0001464218,0.002850563,0.0001778774,0.0009136653],"genre_scores_gemma":[0.983154,0.002092896,0.01267262,0.0002417927,0.00004718587,0.0001102042,0.001339085,0.00004969464,0.0002924074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878474,"threshold_uncertainty_score":0.009934425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05365011858752036,"score_gpt":0.3589040120305977,"score_spread":0.3052538934430773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}