{"id":"W4404116999","doi":"10.1016/j.ekir.2024.10.034","title":"Ancestral Variability in the Genetic Architecture of Urine Uromodulin","year":2024,"lang":"en","type":"letter","venue":"Kidney International Reports","topic":"Pediatric Urology and Nephrology Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Impact; McMaster University; Population Health Research Institute","funders":"","keywords":"Tamm–Horsfall protein; Medicine; Genetic architecture; Urine; Architecture; Evolutionary biology; Internal medicine; Biology; Archaeology; Geography; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001077306,0.0001837359,0.0003564767,0.0003754985,0.0007385598,0.0005286935,0.0003926642,0.004190545,0.001485475],"category_scores_gemma":[0.005771859,0.0001613181,0.0002195482,0.000385624,0.001127617,0.0006167896,0.0004640414,0.00428267,0.0002364519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00057768,"about_ca_system_score_gemma":0.0004082649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003136497,"about_ca_topic_score_gemma":0.00312863,"domain_scores_codex":[0.9993187,0.0002701685,0.00007887292,0.0001170691,0.00012133,0.00009386207],"domain_scores_gemma":[0.9964476,0.002716249,0.000265444,0.0001410522,0.0002130461,0.0002164681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009844564,0.0002463454,0.5011283,0.0002418323,0.0002606809,0.2344505,0.008194236,0.001599908,0.02006036,0.03349235,0.1126855,0.08665571],"study_design_scores_gemma":[0.0002687234,0.0005606572,0.3506404,0.0005992118,0.00036329,0.3664273,0.005560685,0.00502665,0.00813601,0.05956436,0.202696,0.0001567928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4271201,0.00637289,0.002386914,0.5451563,0.003171491,0.0000224806,0.0003594699,0.00006672478,0.01534371],"genre_scores_gemma":[0.9011489,0.003230103,0.00150132,0.07815293,0.01276817,0.00001606553,0.00007819883,0.00003900629,0.003065427],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004190545,"threshold_uncertainty_score":0.006236434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358219483787084,"score_gpt":0.2765523937370477,"score_spread":0.2629701988991769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}