{"id":"W4404119982","doi":"10.1038/s41598-024-78440-0","title":"A novel approach to engineering three-dimensional bladder tumor models for drug testing","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Computer science; Drug; Computational biology; Medicine; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005405585,0.000484208,0.0002519313,0.0005624016,0.0002166417,0.0006680988,0.0005199497,0.0007749511,0.000907897],"category_scores_gemma":[0.0002978596,0.000366334,0.0006940478,0.0002576647,0.0002916775,0.0003848152,0.0004899963,0.0008705445,0.0003970076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002793593,"about_ca_system_score_gemma":0.0005087427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006955685,"about_ca_topic_score_gemma":0.001533978,"domain_scores_codex":[0.9997695,0.00004133948,0.00001792915,0.00003768445,0.0001119758,0.00002153966],"domain_scores_gemma":[0.9997607,0.00004473628,0.00005547698,0.00006879515,0.00004246734,0.00002790861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002611555,0.00007241111,0.0003028828,0.0001269876,0.00001707621,0.0001156136,0.00004154978,0.001940441,0.9871429,0.001334785,0.0002337397,0.008645524],"study_design_scores_gemma":[0.00001464964,0.0004799384,0.001338662,0.00003041036,0.00004927933,0.0007922194,0.00003441712,0.01385851,0.957851,0.0005986939,0.02491604,0.000036176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2836,0.005260185,0.6959081,0.0007626376,0.0004100353,0.0005258766,0.002020619,0.001824288,0.009688174],"genre_scores_gemma":[0.6244346,0.004643626,0.362653,0.0002968729,0.00003467641,0.0006338349,0.001552486,0.0001437356,0.005607191],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.000907897,"threshold_uncertainty_score":0.003037214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04382457101894659,"score_gpt":0.27144822137484,"score_spread":0.2276236503558934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}