{"id":"W4404122216","doi":"10.1016/j.jconrel.2024.10.059","title":"Next-generation 3D printed multipurpose prevention intravaginal ring for prevention of HIV, HSV-2, and unintended pregnancy","year":2024,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention; National Institutes of Health; Partenariat Canadien Contre Le Cancer","keywords":"Vaginal ring; 3d printed; Levonorgestrel; Human immunodeficiency virus (HIV); Drug delivery; Medicine; Chemistry; Pharmacology; Biomedical engineering; Materials science; Virology; Nanotechnology; Population; Family planning","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002941576,0.0001991609,0.0002713406,0.0003036703,0.00009372177,0.0004065733,0.0004527852,0.0004541531,0.002855239],"category_scores_gemma":[0.0004593554,0.0001736751,0.0005040313,0.0000945365,0.0001507176,0.0002625,0.0002815881,0.0003282627,0.0003307119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159942,"about_ca_system_score_gemma":0.0001854834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002898434,"about_ca_topic_score_gemma":0.0004582854,"domain_scores_codex":[0.9997963,0.00003449191,0.000009315814,0.0000307962,0.0001036004,0.00002550121],"domain_scores_gemma":[0.9998615,0.00005870285,0.00003013855,0.00001603473,0.00001903303,0.0000144795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001581044,0.0007898831,0.003632092,0.001494038,0.0001652469,0.001510453,0.000187435,0.004640044,0.606953,0.001849377,0.00361001,0.3735874],"study_design_scores_gemma":[0.0007854391,0.0120756,0.0298327,0.0005744768,0.00118201,0.01524614,0.0003332222,0.05313997,0.7990755,0.001096893,0.08633976,0.0003182064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8106821,0.03555812,0.1327018,0.0009953388,0.001906739,0.000369203,0.001009384,0.001690801,0.01508653],"genre_scores_gemma":[0.9268858,0.004551589,0.06121391,0.0004615997,0.00009389041,0.0001590125,0.0002173406,0.00005474078,0.006362056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002855239,"threshold_uncertainty_score":0.009551704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04499975625142469,"score_gpt":0.3491583927799024,"score_spread":0.3041586365284777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}