{"id":"W4404123848","doi":"10.1038/s41598-024-73672-6","title":"EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Heart Institute; Université de Montréal; Montreal Clinical Research Institute; Diabetes Canada","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Downregulation and upregulation; Adipose tissue; Diabetes mellitus; Medicine; Endocrinology; Internal medicine; Chemistry; Bioinformatics; Biology; Inflammation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009241293,0.0002321335,0.00028399,0.000167003,0.0001056518,0.000159701,0.0001221575,0.0001851865,0.001937071],"category_scores_gemma":[0.0001508414,0.0001004248,0.0002488868,0.00008877725,0.0001156843,0.0001022083,0.0002370679,0.0005234632,0.0003099263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008717368,"about_ca_system_score_gemma":0.0001881618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006994545,"about_ca_topic_score_gemma":0.001027911,"domain_scores_codex":[0.9999295,0.00001964208,0.00001226375,0.00001193036,0.000009815409,0.00001678087],"domain_scores_gemma":[0.999944,0.00001126588,0.00001068771,0.000008717968,0.000008715823,0.00001658414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01791823,0.001313178,0.001053433,0.0003774002,0.0001035794,0.0001242566,0.00008273547,0.000145288,0.9552449,0.0001277903,0.0004592194,0.02305007],"study_design_scores_gemma":[0.001821402,0.01573519,0.03676363,0.0001161948,0.0002861438,0.0004933757,0.0001625465,0.001915685,0.9294907,0.0005503439,0.0126404,0.00002445018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986937,0.008616096,0.00142471,0.0002756962,0.00009737247,0.00006123297,0.0006951743,0.00008262413,0.001810122],"genre_scores_gemma":[0.9898634,0.003759733,0.001549361,0.000208211,0.00002776027,0.0001040275,0.000878991,0.00001750031,0.003591162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937071,"threshold_uncertainty_score":0.006480098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177340579446513,"score_gpt":0.281580014440987,"score_spread":0.2638459564963357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}