{"id":"W4404125687","doi":"10.1200/po-24-00375","title":"DNA Methylation Classes of Stage II and III Primary Melanomas and Their Clinical and Prognostic Significance","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Pfizer; University of Texas MD Anderson Cancer Center; University of North Carolina at Chapel Hill; National Institutes of Health; Melanoma Institute Australia; Medical Research Council; National Health and Medical Research Council; Huntsman Cancer Foundation; Char and Chuck Fowler Family Foundation; National Cancer Institute; Melanoma Research Alliance; National Institute of Environmental Health Sciences; Memorial Sloan-Kettering Cancer Center","keywords":"Stage (stratigraphy); DNA methylation; Methylation; Primary (astronomy); Clinical significance; Biology; DNA; Cancer research; Oncology; Medicine; Genetics; Internal medicine; Gene; Gene expression; Paleontology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000729333,0.0001216391,0.0004201517,0.0001548221,0.00006291502,0.00001934358,0.00003250816,0.000164987,0.00007346726],"category_scores_gemma":[0.0002674641,0.0000876572,0.00004314009,0.0001147456,0.0002196289,0.00005924797,0.0001602378,0.0001973669,0.000002911447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004234795,"about_ca_system_score_gemma":0.0001042589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104363,"about_ca_topic_score_gemma":0.00002575178,"domain_scores_codex":[0.9988058,0.0001494315,0.0004391836,0.000369616,0.0001157031,0.0001202568],"domain_scores_gemma":[0.998282,0.001314459,0.00009379914,0.0001475825,0.00005214191,0.0001099731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008597047,0.0002211632,0.005998978,0.0004133616,0.0001499104,0.0001249105,0.0007815745,0.00000126015,0.02944283,0.0009278713,0.001612624,0.9594658],"study_design_scores_gemma":[0.003631566,0.009899479,0.1901807,0.0003795797,0.0003724428,0.0006943553,0.0009484861,0.003289083,0.005260578,0.001973649,0.7830873,0.0002827544],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864874,0.003684774,0.001902949,0.001377659,0.0004510987,0.000778421,0.000008795844,0.00007243559,0.005236437],"genre_scores_gemma":[0.992989,0.002149168,0.001314322,0.0002349045,0.0001084584,0.00002642134,0.000007726391,0.00001411935,0.003155902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.959183,"threshold_uncertainty_score":0.3574557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03563761992787889,"score_gpt":0.3467736763202066,"score_spread":0.3111360563923277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}