{"id":"W4404125687","doi":"10.1200/po-24-00375","title":"DNA Methylation Classes of Stage II and III Primary Melanomas and Their Clinical and Prognostic Significance","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Pfizer; University of Texas MD Anderson Cancer Center; University of North Carolina at Chapel Hill; National Institutes of Health; Melanoma Institute Australia; Medical Research Council; National Health and Medical Research Council; Huntsman Cancer Foundation; Char and Chuck Fowler Family Foundation; National Cancer Institute; Melanoma Research Alliance; National Institute of Environmental Health Sciences; Memorial Sloan-Kettering Cancer Center","keywords":"Stage (stratigraphy); DNA methylation; Methylation; Primary (astronomy); Clinical significance; Biology; DNA; Cancer research; Oncology; Medicine; Genetics; Internal medicine; Gene; Gene expression; Paleontology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693022,0.0002227848,0.0002466374,0.0007880019,0.0002804673,0.0003804037,0.0001965832,0.0002458493,0.001251779],"category_scores_gemma":[0.001042339,0.0001348748,0.0001950499,0.0004391676,0.0002213526,0.0001658673,0.0002711174,0.0002579188,0.0002090094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002382342,"about_ca_system_score_gemma":0.0001312281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002441795,"about_ca_topic_score_gemma":0.003134234,"domain_scores_codex":[0.9997408,0.00004408899,0.00002987999,0.00009153807,0.0000449918,0.00004856703],"domain_scores_gemma":[0.9993756,0.00009162776,0.0003194953,0.00004886404,0.00006574672,0.00009865141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001363074,0.000009255916,0.995872,0.000007103074,0.00002407228,0.00003796923,0.00003987472,0.0000247863,0.001880647,0.00001307429,0.00005245299,0.001902444],"study_design_scores_gemma":[0.000003624473,0.00004712448,0.9986734,0.00000312857,0.00001386493,0.0003909224,0.00007113691,0.0001669052,0.0004378173,0.00003560506,0.0001545476,0.000001915764],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988614,0.0002765087,0.0001686624,0.00001611573,0.000002208713,0.000008080893,0.0003913848,0.000005556126,0.000270032],"genre_scores_gemma":[0.9993787,0.00004309224,0.0001116737,0.000008430933,0.000003552886,0.000005974881,0.0003375984,0.000001766327,0.0001092425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002441795,"threshold_uncertainty_score":0.004855216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03563761992787889,"score_gpt":0.3467736763202066,"score_spread":0.3111360563923277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}