{"id":"W4404126970","doi":"10.1093/hmg/ddae162","title":"SMN depletion impairs skeletal muscle formation and maturation in a mouse model of SMA","year":2024,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; Ottawa Hospital","funders":"Muscular Dystrophy Canada; Canadian Institutes of Health Research; University of Ottawa; Cure SMA; Muscular Dystrophy Association","keywords":"Biology; SMA*; Skeletal muscle; Cell biology; Anatomy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004884329,0.001008676,0.0006102194,0.001503255,0.0003635936,0.0004272488,0.0005215217,0.00129526,0.002611702],"category_scores_gemma":[0.0002141202,0.0005892947,0.0005489764,0.0003598946,0.0005961802,0.0004008235,0.0004528785,0.001253456,0.0008467435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004677713,"about_ca_system_score_gemma":0.0002817121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009325778,"about_ca_topic_score_gemma":0.002050543,"domain_scores_codex":[0.999587,0.0000916128,0.00005707985,0.00009928783,0.00009314091,0.00007185767],"domain_scores_gemma":[0.9995789,0.00004771401,0.0001385426,0.00002974668,0.00002655783,0.0001785356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004377751,0.0001935256,0.0003653665,0.00005284971,0.0000192637,0.0001833013,0.00003524689,0.0001652038,0.9971302,0.0001325019,0.00009776581,0.001187014],"study_design_scores_gemma":[0.0003799228,0.005403849,0.0281573,0.0001758677,0.0001741005,0.002213819,0.0002378052,0.005745758,0.9501678,0.0004229402,0.006882109,0.00003871452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903448,0.002219223,0.003158923,0.0003331728,0.0000891654,0.0001060271,0.001450094,0.0003452824,0.001953242],"genre_scores_gemma":[0.9783148,0.002217566,0.005812542,0.0002552409,0.00003038045,0.0003381885,0.001957637,0.0001565276,0.01091715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002611702,"threshold_uncertainty_score":0.008736968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02356502983262249,"score_gpt":0.2990020618600189,"score_spread":0.2754370320273964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}