{"id":"W4404137834","doi":"10.1183/13993003.00691-2024","title":"Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma","year":2024,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; St. Joseph’s Healthcare Hamilton; Centre Hospitalier de l’Université de Montréal; McMaster University; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto","funders":"NIHR Leicester Biomedical Research Centre; NIHR Imperial Biomedical Research Centre; Manchester Biomedical Research Centre; Genentech; National Institute for Health Research Southampton Biomedical Research Centre; Engineering and Physical Sciences Research Council; Bausch Health; Karl-Franzens-Universität Graz; Innovative Medicines Initiative; Shionogi; Universiteit van Amsterdam; European Respiratory Society; Nestlé Health Science; Rijksuniversiteit Groningen; Celltrion; Pfizer; Incyte; European Federation of Pharmaceutical Industries and Associations; Celldex Therapeutics; AAIR Charity; University of Southampton; Imperial Experimental Cancer Medicine Centre; Vertex Pharmaceuticals; Chiesi Farmaceutici; University of Otago; Regeneron Pharmaceuticals; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Karolinska Institutet; ZonMw; Aimmune Therapeutics; Eli Lilly and Company; AstraZeneca; Novartis Pharma; European Commission; Sanofi; Cerecor; Amgen; Medizinische Universität Graz; GlaxoSmithKline","keywords":"Medicine; Asthma; Quality of life (healthcare); Physical therapy; Intensive care medicine; Pediatrics; Internal medicine; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01858663,0.0007643419,0.0009789071,0.003402557,0.0002967264,0.001439253,0.0008998446,0.0006749093,0.002053642],"category_scores_gemma":[0.03982516,0.0002171126,0.001729149,0.002284135,0.0005115184,0.0009811098,0.001843042,0.00111895,0.0004322368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009193977,"about_ca_system_score_gemma":0.001168471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007173506,"about_ca_topic_score_gemma":0.001672676,"domain_scores_codex":[0.9840608,0.007837012,0.002324155,0.0007607397,0.004657011,0.0003602106],"domain_scores_gemma":[0.9600678,0.01715108,0.01429541,0.001507349,0.005448909,0.001529419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001758832,0.000485418,0.8330274,0.0006510148,0.0008260579,0.00011902,0.001050738,0.005000528,0.001054889,0.001074271,0.004336584,0.1506152],"study_design_scores_gemma":[0.0002019171,0.002189857,0.9787607,0.0001973104,0.0002355289,0.0004221587,0.0004874161,0.01069037,0.001345789,0.001259728,0.004129459,0.00007995636],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9233447,0.002308403,0.04823504,0.0007732079,0.0002893317,0.003050055,0.005906943,0.0005431959,0.0155491],"genre_scores_gemma":[0.9473336,0.0004059229,0.04720287,0.0002084151,0.0001010724,0.001947926,0.002262087,0.00004743907,0.0004905589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01858663,"threshold_uncertainty_score":0.09829664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04137620043987025,"score_gpt":0.3163745504632727,"score_spread":0.2749983500234025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}