{"id":"W4404139952","doi":"10.1080/21678421.2024.2403306","title":"Theme 9 Clinical Trials and Trial Design","year":2024,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Health Canada; Mitsubishi Tanabe Pharma Corporation; U.S. Department of Defense; PTC Therapeutics; Government of Canada; MND Scotland; National Institute for Health and Care Research; Fondation Brain Canada; Regeneron Pharmaceuticals; Biogen; ALS Society of Canada; Alnylam Pharmaceuticals; Motor Neurone Disease Association","keywords":"Theme (computing); Clinical trial; Medicine; Medical physics; Computer science; Internal medicine; World Wide Web","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0997455,0.002601424,0.005729016,0.001708,0.00132978,0.00424792,0.002664061,0.006259471,0.09330703],"category_scores_gemma":[0.108515,0.002267342,0.006703768,0.001878215,0.002541678,0.002339786,0.003321054,0.007162863,0.01789484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002867832,"about_ca_system_score_gemma":0.01209639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006787744,"about_ca_topic_score_gemma":0.001721444,"domain_scores_codex":[0.8730791,0.1076063,0.007184402,0.004981196,0.004153315,0.002995747],"domain_scores_gemma":[0.9548787,0.02454481,0.006275591,0.007683597,0.003834681,0.002782485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.5204124,0.002563606,0.00319476,0.04912364,0.01754958,0.0003612501,0.0006361074,0.00394101,0.001870941,0.05535937,0.1887408,0.1562465],"study_design_scores_gemma":[0.6659471,0.01853811,0.003028098,0.006895102,0.007476358,0.000212389,0.0000869704,0.003997227,0.0009351136,0.04271841,0.2500019,0.0001631934],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"other","genre_scores_codex":[0.01994588,0.01958431,0.08517247,0.01747433,0.01121932,0.7497036,0.04251557,0.002054503,0.05233006],"genre_scores_gemma":[0.04096586,0.002506283,0.04530855,0.008704548,0.001402377,0.8843573,0.00263226,0.0002159887,0.01390682],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.906693,"threshold_uncertainty_score":0.5275109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3285539512277282,"score_gpt":0.4278464151405864,"score_spread":0.09929246391285818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}