{"id":"W4404139952","doi":"10.1080/21678421.2024.2403306","title":"Theme 9 Clinical Trials and Trial Design","year":2024,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Health Canada; Mitsubishi Tanabe Pharma Corporation; U.S. Department of Defense; PTC Therapeutics; Government of Canada; MND Scotland; National Institute for Health and Care Research; Fondation Brain Canada; Regeneron Pharmaceuticals; Biogen; ALS Society of Canada; Alnylam Pharmaceuticals; Motor Neurone Disease Association","keywords":"Theme (computing); Clinical trial; Medicine; Medical physics; Computer science; Internal medicine; World Wide Web","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005133514,0.0003705547,0.00106708,0.0001709648,0.0002422573,0.000605152,0.00009447864,0.0004060102,0.0002760426],"category_scores_gemma":[0.0003860698,0.0002484166,0.000293615,0.0002206691,0.0002633753,0.0005182339,0.0001107592,0.0005146149,0.00005235471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009911488,"about_ca_system_score_gemma":0.0001650207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002774155,"about_ca_topic_score_gemma":0.00001799845,"domain_scores_codex":[0.9953194,0.001378183,0.001409613,0.000882989,0.0005371097,0.0004726899],"domain_scores_gemma":[0.9984951,0.0004119923,0.0001497903,0.0003294625,0.0001132782,0.0005003906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.09201413,0.001022255,0.01907379,0.0006787995,0.001845539,0.0003775725,0.001518261,0.000073166,0.334782,0.008974735,0.04162983,0.4980099],"study_design_scores_gemma":[0.1522192,0.01999791,0.5745091,0.002717254,0.002188515,0.000383222,0.0001241036,0.2119915,0.004468981,0.01043461,0.01812557,0.002840062],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782123,0.007009912,0.004679279,0.006945149,0.0009187702,0.00190407,0.00001998461,0.0002093031,0.0001012077],"genre_scores_gemma":[0.9859755,0.005624992,0.004225524,0.0005139479,0.002229298,0.0001398808,0.00007743548,0.00006209461,0.001151321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5554353,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3285539512277282,"score_gpt":0.4278464151405864,"score_spread":0.09929246391285818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}