{"id":"W4404141141","doi":"10.1021/acs.orglett.4c03688","title":"Enabling Unfavorable Hydroamination Reactions Using a Chemoselective N–O Bond Reduction","year":2024,"lang":"en","type":"article","venue":"Organic Letters","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; University of Ottawa","keywords":"Hydroamination; Chemistry; Reduction (mathematics); Combinatorial chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165253,0.0004367374,0.0001709466,0.0001299304,0.0001204139,0.0002949062,0.0003188401,0.000324451,0.001396188],"category_scores_gemma":[0.0002560907,0.0001644785,0.0001589361,0.00007509853,0.0002416584,0.0003961982,0.0004993525,0.000534295,0.0005636227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760116,"about_ca_system_score_gemma":0.0002213841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002479063,"about_ca_topic_score_gemma":0.001065748,"domain_scores_codex":[0.9997947,0.00002484069,0.00001570813,0.00006384031,0.00005719597,0.00004375546],"domain_scores_gemma":[0.9999233,0.00001731434,0.0000233721,0.00001324348,0.00001195024,0.00001076935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004888674,0.00002130693,0.00008076019,0.0001243655,0.000007552662,0.00009556874,0.00001896603,0.0001101825,0.9947147,0.0005521916,0.0001067391,0.004118813],"study_design_scores_gemma":[0.000008635031,0.0002086319,0.0004375702,0.000007125318,0.000009709748,0.0002335528,0.00001759471,0.000703163,0.992574,0.0001528344,0.005637511,0.000009759238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9319673,0.003719507,0.04401835,0.000361589,0.0001839704,0.0002001849,0.0003053417,0.0003939547,0.01884974],"genre_scores_gemma":[0.9880434,0.001222605,0.007772196,0.00008331854,0.00001632005,0.00003734532,0.000125736,0.00002536193,0.002673733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001396188,"threshold_uncertainty_score":0.00467068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149276745143442,"score_gpt":0.2379683549125273,"score_spread":0.2264755874610929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}