{"id":"W4404141847","doi":"10.1021/acs.jmedchem.4c01172","title":"Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; Pfizer; National Science Foundation","keywords":"Chemistry; Prostate cancer; PTEN; Prostate; Cancer research; Cancer; Pharmacology; Internal medicine; Biochemistry; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562718,0.000491373,0.0004389627,0.0003718499,0.0001915995,0.0003971834,0.0003913648,0.0002992789,0.001481658],"category_scores_gemma":[0.0001143894,0.0002240888,0.0002619747,0.0002360856,0.0001524953,0.0001276591,0.000223266,0.0007813419,0.0004348902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003523185,"about_ca_system_score_gemma":0.0003442024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005753025,"about_ca_topic_score_gemma":0.002562458,"domain_scores_codex":[0.9999349,0.00001012947,0.000003391385,0.000009897824,0.00001997868,0.00002174265],"domain_scores_gemma":[0.9999599,0.000005884515,0.000007295938,0.000002167048,0.000006864601,0.00001786865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004408879,0.0003645737,0.0003821171,0.0002336218,0.00007936364,0.0003001126,0.00004928934,0.00102636,0.9636848,0.001012227,0.001694218,0.03073241],"study_design_scores_gemma":[0.001049412,0.00598027,0.00547501,0.00004819697,0.0002173673,0.00169087,0.00006680087,0.005285591,0.9369043,0.0003692609,0.04285933,0.00005369582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600894,0.01457614,0.00992315,0.000807143,0.0001919756,0.000606651,0.001616693,0.0006104867,0.01157842],"genre_scores_gemma":[0.9712459,0.0106552,0.006840374,0.0004443302,0.00003625758,0.0002345221,0.001928051,0.00004438019,0.008571115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481658,"threshold_uncertainty_score":0.004956603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00970312426298291,"score_gpt":0.3054785647486962,"score_spread":0.2957754404857132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}