{"id":"W4404142527","doi":"10.1002/gcc.70006","title":"Malignant Peripheral Nerve Sheath Tumor (<scp>MPNST</scp>) With Smooth Muscle Differentiation of the Uterus—A Case Report With Emphasis on Diagnostic Pitfalls and Value of <scp>DNA</scp> Methylation Analysis","year":2024,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Health and Medical Research Fund","keywords":"Biology; Malignant peripheral nerve sheath tumor; DNA methylation; Uterus; Cell biology; Methylation; Cancer research; Pathology; Endocrinology; DNA; Immunohistochemistry; Immunology; Genetics; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370965,0.0002662247,0.0005682652,0.0001713889,0.0001141909,0.0000672631,0.0000561794,0.00006029783,0.00001956947],"category_scores_gemma":[0.00006937922,0.0001487721,0.0001586272,0.0006239018,0.000148834,0.0001177914,0.00004583071,0.00009874043,2.040169e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004856389,"about_ca_system_score_gemma":0.0001381019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006069751,"about_ca_topic_score_gemma":0.0002199426,"domain_scores_codex":[0.9983776,0.00008260666,0.0004111692,0.0004985735,0.0004054413,0.0002246771],"domain_scores_gemma":[0.9987566,0.000376386,0.0002598035,0.0003756759,0.0001132113,0.0001183305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001189713,0.0005734519,0.808989,0.002960316,0.003865782,0.02144,0.005211883,0.002227805,0.1261222,0.0005738139,0.0004380208,0.02747872],"study_design_scores_gemma":[0.00119158,0.001353149,0.8510524,0.001062544,0.004265259,0.004880147,0.001045137,0.002869607,0.130827,0.00002498558,0.001317143,0.0001109891],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877804,0.01122857,0.000111303,0.0001017385,0.0001085292,0.00042573,0.0001446962,0.0000296456,0.00006936915],"genre_scores_gemma":[0.9983211,0.0009994581,0.0001291849,0.00006363,0.0001029891,0.00007873195,0.00003421764,0.00003758121,0.0002330767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04206338,"threshold_uncertainty_score":0.6066752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139988459919232,"score_gpt":0.2504321070392005,"score_spread":0.2390322224400082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}