{"id":"W4404143498","doi":"10.1038/s44319-024-00314-3","title":"In situ cell-surface conformation of the TCR-CD3 signaling complex","year":2024,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; NYU Grossman School of Medicine; University of Illinois at Urbana-Champaign; National Cancer Institute; Yale University; National Institutes of Health; McMaster University; Foundation for the National Institutes of Health","keywords":"T-cell receptor; In situ; Cell biology; Signal transduction; Chemistry; Biology; T cell; Genetics; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002475841,0.00007185254,0.0001137711,0.00004987868,0.00005557994,0.00001008283,0.00004684536,0.00008882307,0.001672834],"category_scores_gemma":[0.00002457442,0.0000522551,0.00007453698,0.0001270353,0.00004106944,0.000155163,0.00003004693,0.0002061402,0.0001967557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003613091,"about_ca_system_score_gemma":0.00004245975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009160642,"about_ca_topic_score_gemma":0.00000793198,"domain_scores_codex":[0.9992817,0.0000679159,0.0003961732,0.000115791,0.00003082815,0.0001075884],"domain_scores_gemma":[0.9995954,0.00004665735,0.000141717,0.0001734454,0.00003824983,0.000004517573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001386187,0.00002506274,0.000300425,0.0000367558,0.00001877361,0.00001118265,0.0007434524,0.0002030626,0.9595367,0.0001244769,0.03881907,0.0001671786],"study_design_scores_gemma":[0.0001047847,0.00002250329,0.001649111,0.00005949613,0.00001179255,0.0002499554,0.0003183528,0.00006875395,0.7391962,0.00007829202,0.2581812,0.00005960912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947546,0.001409067,0.0002154005,0.0002992502,0.00971526,0.000173312,6.919237e-7,0.00004724937,0.04059375],"genre_scores_gemma":[0.9789392,0.00001493729,0.0000141331,0.0001330509,0.00001388302,0.000002622954,0.0000376198,0.000006207472,0.02083833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2203405,"threshold_uncertainty_score":0.9992397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425875251250545,"score_gpt":0.2436978944261188,"score_spread":0.2294391419136134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}