{"id":"W4404167203","doi":"10.4049/jimmunol.212.supp.0445.5642","title":"CRISPR Screens Identify Key Regulators of NK Cell Cytotoxicity in Cancer Therapy","year":2024,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"CRISPR; Cytotoxicity; Key (lock); Cancer therapy; Cancer; Cancer research; Computational biology; Biology; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003032474,0.0005539694,0.0006523936,0.0003406766,0.0002240929,0.0007228061,0.0003911783,0.0005602129,0.003879218],"category_scores_gemma":[0.0002858265,0.0001992335,0.0003844027,0.0002032967,0.0002901011,0.0001874936,0.0004230441,0.0007287765,0.001038171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004537072,"about_ca_system_score_gemma":0.0003560576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005392437,"about_ca_topic_score_gemma":0.0008848429,"domain_scores_codex":[0.9996486,0.00005188908,0.00004030879,0.000074029,0.0001290309,0.0000561273],"domain_scores_gemma":[0.9998134,0.000054359,0.00004448727,0.00002704638,0.00003091979,0.00002992305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001368686,0.0000401225,0.0004655612,0.0001795241,0.00002331943,0.0001925637,0.00001817152,0.001206681,0.9875186,0.0006328616,0.0006210661,0.00896459],"study_design_scores_gemma":[0.0000457815,0.0004062094,0.002663953,0.00004005537,0.00009974493,0.0006934025,0.00004320461,0.005266496,0.9632264,0.0004100602,0.02708052,0.00002402544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8521467,0.01177683,0.09650286,0.00128881,0.000543887,0.0007690493,0.007682074,0.004601903,0.02468788],"genre_scores_gemma":[0.9634671,0.003110476,0.02130069,0.0003406973,0.00002965354,0.0003004611,0.002466355,0.0002712926,0.008713454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003879218,"threshold_uncertainty_score":0.0129773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770953234923421,"score_gpt":0.2850752473295664,"score_spread":0.2673657149803322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}