{"id":"W4404167446","doi":"10.4049/jimmunol.212.supp.1567.6096","title":"Fractionation of mRNA vaccines improves immune responses","year":2024,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Immune system; Messenger RNA; Fractionation; Biology; Immunology; Virology; Computational biology; Chemistry; Genetics; Gene; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636043,0.0004089555,0.0003797518,0.0002155382,0.00007896865,0.0002303843,0.0001518458,0.0002620084,0.001145812],"category_scores_gemma":[0.000177497,0.00008934311,0.0002253815,0.0001037356,0.0001946251,0.0001764818,0.0001464933,0.0007148454,0.0003264669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387451,"about_ca_system_score_gemma":0.0001463608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003159868,"about_ca_topic_score_gemma":0.0004063383,"domain_scores_codex":[0.9998444,0.00002210804,0.0000133875,0.00003584869,0.00003679231,0.00004740727],"domain_scores_gemma":[0.9998443,0.0000415935,0.00004345327,0.00002084883,0.00002306285,0.00002669669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009534526,0.00004218941,0.00006172972,0.00002115913,0.000002600348,0.000006203432,0.000004838804,0.0001024163,0.9976407,0.00002105167,0.00002758331,0.001974081],"study_design_scores_gemma":[0.00003143617,0.003089947,0.002451183,0.00001042564,0.00002360117,0.00007299759,0.00001853921,0.000997676,0.9916394,0.00006187153,0.001598013,0.0000048991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911757,0.001336984,0.005768285,0.0001157668,0.0001037684,0.00006475483,0.000156261,0.0001639356,0.001114598],"genre_scores_gemma":[0.9941654,0.0004754227,0.003298302,0.0001509976,0.0000416988,0.00003745496,0.0002367122,0.00003082419,0.001563217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145812,"threshold_uncertainty_score":0.003833115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009382761132483496,"score_gpt":0.2645549029558199,"score_spread":0.2551721418233364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}