{"id":"W4404167560","doi":"10.1038/s41467-024-54096-2","title":"PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ruijin Hospital; Engineering and Physical Sciences Research Council; Faculty of Medicine and Health, University of Sydney; Translational Cancer Research Network; Hebei University of Engineering; Centre for Blood Research, University of British Columbia; Chinesisch-Deutsche Zentrum für Wissenschaftsförderung; Hebei University; Kids Cancer Alliance; Shanghai Jiao Tong University; University of New South Wales; Research Councils UK; University of Technology Sydney; Science and Technology Commission of Shanghai Municipality; Biotechnology and Biological Sciences Research Council; University of Sydney; Deutsche Forschungsgemeinschaft; National Natural Science Foundation of China; School of Medicine, Shanghai Jiao Tong University; National Health and Medical Research Council; Kay Kendall Leukaemia Fund; Medical Research Council; Yorkshire Forward; Neuroscience Research Australia","keywords":"Lymphoblastic Leukemia; Chromatin; Glucocorticoid; Cancer research; Immunology; Leukemia; Lymphocyte; Medicine; Biology; Genetics; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238302,0.000152451,0.0001918854,0.0001608701,0.0001423022,0.0002453767,0.0001227696,0.0001582722,0.001611721],"category_scores_gemma":[0.0001854572,0.000101852,0.0001408576,0.0001065153,0.0001992101,0.0001567405,0.000212061,0.0004947379,0.0003078502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572003,"about_ca_system_score_gemma":0.0001359572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153946,"about_ca_topic_score_gemma":0.000399463,"domain_scores_codex":[0.9998872,0.00002501122,0.000005106804,0.00001436959,0.00002760038,0.00004065445],"domain_scores_gemma":[0.9999028,0.00002328597,0.00003048589,0.00001049758,0.00000605914,0.00002676015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002075191,0.00003155725,0.0006275026,0.00003550508,0.000004133277,0.00007587836,0.0000206998,0.00007975002,0.99546,0.0002345819,0.00009363026,0.003129224],"study_design_scores_gemma":[0.00004818083,0.0007634573,0.03356671,0.000009407056,0.00001965493,0.0007615881,0.00008885844,0.001195949,0.9566436,0.0003640247,0.00653111,0.000007494411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923049,0.003924067,0.002279966,0.0001648581,0.00003302265,0.00001666952,0.0001033526,0.00009976231,0.001073378],"genre_scores_gemma":[0.9977703,0.0007847939,0.0005050518,0.00004007895,0.00001244305,0.00001294946,0.0001418258,0.000007261656,0.0007252037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611721,"threshold_uncertainty_score":0.005391717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737198861805142,"score_gpt":0.3165889715470135,"score_spread":0.2992169829289621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}